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Rabbit Anti-TBRG1/Gold Conjugated antibody (bs-4268R-Gold)
訂購熱線:400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-4268R-Gold
英文名稱 Rabbit Anti-TBRG1/Gold Conjugated antibody
中文名稱 膠體金標記的轉(zhuǎn)化生長因子β調(diào)節(jié)蛋白1抗體
別    名 NIAM; Nuclear interactor of ARF and Mdm2; Transforming growth factor beta regulator 1; TBRG1; TBRG-1; TBRG 1; Transforming growth factor beta regulator 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  細胞生物  免疫學  染色質(zhì)和核信號  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TBRG1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Acts as a growth inhibitor. Can activate TP53/p53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. There are two isoforms.

Function:
Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.

Subunit:
Interacts with CDKN2A and MDM2.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma.

Post-translational modifications:
Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation.

Similarity:
Belongs to the TBRG1 family.
Contains 1 FYR C-terminal domain.
Contains 1 FYR N-terminal domain.

Database links:

Entrez Gene: 84897 Human

Entrez Gene: 21376 Mouse

Entrez Gene: 300521 Rat

Omim: 610614 Human

SwissProt: Q3YBR2 Human

SwissProt: Q3UB74 Mouse

SwissProt: Q5PQK8 Rat

Unigene: 436410 Human

Unigene: 28689 Mouse

Unigene: 129282 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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