97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
日本黄色三级,欧美一级片免费观看,日本亚洲高清
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-VAV3/AP Conjugated antibody (bs-4286R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-4286R-AP
英文名稱 Rabbit Anti-VAV3/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的鳥嘌呤核苷酸交換因子VAV3抗體
別    名 Guanine nucleotide exchange factor VAV3; Protein vav 3; Protein vav3; VAV 3; Vav 3 guanine nucleotide exchange factor; VAV 3 oncogene; VAV 3 protein; VAV-3; Vav3; VAV3 oncogene; VAV3 protein; VAV3_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  信號轉(zhuǎn)導  轉(zhuǎn)錄調(diào)節(jié)因子  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應用 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 97kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VAV3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate signaling events following lymphocyte antigen receptor activation. Vav3, like Vav (also known as Vav1 or p95Vav), undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, and subsequently interacts with 2 adaptor molecules, SLP76 and 3BP2. Following these events, however, the paths of Vav and Vav3 diverge; Vav affects IL-2 promotor activity, while Vav3 impacts gene transcription linked to serum response element (SRE). Furthermore, Vav3 expression follows a cell cycle-dependent pattern, with transient upregulation occuring during mitosis. Encforced Vav3 expression leads to the appearance of multinucleate cells, implicating a role for Vav3 in the control of cytokinesis.

Function:
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).

Subunit:
Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation.

Tissue Specificity:
Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.

Post-translational modifications:
Phosphorylated. Phosphorylation can be mediated by ROS1. In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1 (By similarity).

Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 SH2 domain.
Contains 2 SH3 domains.

Database links:

Entrez Gene: 10451 Human

Entrez Gene: 57257 Mouse

Omim: 605541 Human

SwissProt: Q9UKW4 Human

SwissProt: Q9R0C8 Mouse

Unigene: 267659 Human

Unigene: 282257 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

癌基因Vav3屬于Vav家族癌基因蛋白類,它含有多個功能單位,主要通過信號傳導,參與了腫瘤的發(fā)生發(fā)展過程,包括細胞骨架重組、鈣離子內(nèi)流、調(diào)控基因轉(zhuǎn)錄、對細胞可塑性和遷移的調(diào)節(jié),對維持細胞形態(tài),細胞的粘附,血管的生成,免疫細胞的調(diào)節(jié),細胞的分化等發(fā)揮著作用。Vav3表達的失調(diào)與腫瘤的發(fā)生有一定的關聯(lián),并有著原癌基因的活性。
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 97无码视频在线看视频 | 国产精品黑人 | 日韩在线看片免费人成视频播放 | 国产三区视频 | 久久久亚洲精品中文字幕 | 国产精品线在线精品 | 色日韩综合 | 日本护士体内SHE精2╳╳╳ | 久久99久久久久久 | av中文在线资源 | 午夜影视在线 | 伊人成色综合网 | 丰满少妇人妻无码 | 国产系列视频二区 | 亚洲精品美女视频在线观看 | 久久日韩国产精品免费 | 免费观看又色又爽又黄的校园 | 亚洲中文成人中文字幕 | 亚洲视频www | 肉岳疯狂69式激情的高潮 | 国产午夜精品久久久久久免费视 | 办公室扒开奶罩揉吮奶头AV | 暴力调教一区二区三区 | 亚洲华人play视频在线 | AV无码岛国免费动作片 | 二区免费 | 性爱无码视频在线看 | 欧美日韩一区二区国产 | 不卡在线一区2区三区 | 久久99国产精品亚洲 | 久久综合狠狠综合 | 受被攻c哭高h视频在线观看 | av蜜臀| 国产日韩二区 | 久久精品亚洲精品无码金尊 | 麻豆亚洲av永久无码精品久久 | 麻豆国产一区二区三区 | 扒开粉嫩的小缝隙喷白浆 | 一人之下2在线观看 | 国产精品12区 | 国产成人精品视频免费 |