97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
天天操天天干天天爽,不卡在线视频,99c视频高清免费观看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-OA1/Cy5 Conjugated antibody (bs-11791R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11791R-Cy5
英文名稱 Rabbit Anti-OA1/Cy5 Conjugated antibody
中文名稱 Cy5標記的眼部白化病相關蛋白OA1/蛋白偶聯受體143抗體
別    名 ALBINISM OCULAR TYPE I; G protein coupled receptor 143; G-protein coupled receptor 143; GP143_HUMAN; GPR143; MOA1; NETTLESHIP FALLS TYPE OCULAR ALBINISM; Ocular albinism type 1 protein; Ocular albinism type 1 protein homolog; Ocular albinism1 Nettleship Falls type.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human OA1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
G protein-coupled receptors (GPRs or GPCRs), are members of the largest protein family and play a role in many different stimulus-response pathways. G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation). They respond to a great variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR143, also designated ocular albinism type 1 protein (OA1), is detected exclusively in pigment cells. OA1, which is a multi-pass membrane protein, is a melanosomal protein expressed primarily in pigment cells. Defects in the gene encoding for OA1 cause ocular albinism, an X-linked disorder mainly characterized by retinal hypopigmentation and visual impairment.

Function:
Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.

Subunit:
Interacts with heterotrimeric G(i) proteins. Interacts with ARRB1 and ARRB2. Interacts with MLANA.

Subcellular Location:
Golgi apparatus. Melanosome membrane. Lysosome membrane. Apical cell membrane. Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine.

Tissue Specificity:
Expressed at high levels in the retina, including the retinal pigment epithelium (RPE), and in melanocytes. Weak expression is observed in brain and adrenal gland.

Post-translational modifications:
Glycosylated.
Phosphorylated.

DISEASE:
Defects in GPR143 are the cause of albinism ocular type 1 (OA1) [MIM:300500]; also known as Nettleship-Falls type ocular albinism. Form of albinism affecting only the eye. Pigment of the hair and skin is normal or only slightly diluted. Eyes may be severely affected with photophobia and reduced visual acuity. Nystagmus or strabismus are often associated. The irides and fundus are depigmented.
Defects in GPR143 are the cause of Nystagmus congenital X-linked type 6 (NYS6) [MIM:300814]. It is a condition defined as conjugated, spontaneous and involuntary ocular oscillations that appear at birth or during the first three months of life. Other associated features may include mildly decreased visual acuity, strabismus, astigmatism, and occasionally head nodding.

Similarity:
Belongs to the G-protein coupled receptor OA family.

Database links:

Entrez Gene: 4935 Human

Entrez Gene: 18241 Mouse

Entrez Gene: 302619 Rat

Omim: 300500 Human

SwissProt: P51810 Human

SwissProt: P70259 Mouse

Unigene: 74124 Human

Unigene: 5157 Mouse

Unigene: 141649 Rat

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 久久久久久久爱 | 一区二区三区四区免费在线观看 | china国语对白刺激videos 97视频久久 | a级国产乱理伦片在线观看 www在线免费 | 天堂а在线最新版在线 | 欧美成人家庭影院 | 国产一卡二卡三卡四卡 | 国产三级日本三级在线播放 | 35岁少妇被23岁小伙征服 | 亚洲日韩在线中文字幕线路2区 | 无码AV免费一区二区三区四区 | 国产精品一区二区福利视频 | 国产网红主播精品一区二区三区 | 精品久久久久久18免费网站 | 亚洲精品中文字幕无码av | 国产精品porn| 一区二区三区四区视频免费观看 | 国产尤物小视频在线观看 | 亚洲国产精品无码一线岛国 | 特黄免费av | 激性欧美激情在线 | 蜜桃视频无码区在线观看 | 在线精品亚洲一区二区 | 91免费 | 国产毛片毛片毛片毛片毛片 | 大尺度做爰黄9996片视频 | 四虎新影院2019址 | 国产女人在线75视频 | 人人摸人人操 | 亚洲中文字幕无码久久2017 | 久久精品免费 | 伊人一区二区三区 | yy6080午夜我不卡 | 国内毛片毛片毛片毛片毛片毛片 | 5252色成人免费视频 | 热99RE久久精品这里都是精品免费 | 国产69精品99久久久久久宅男 | 午夜香吻高清观看视频在线 | 久久久久久久人妻无码中文字幕爆 | 一色一伦一区二区三区 | 国产日产久久久久久 |