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Rabbit Anti-NEURL/BF350 Conjugated antibody (bs-11897R-BF350)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11897R-BF350
英文名稱 Rabbit Anti-NEURL/BF350 Conjugated antibody
中文名稱 BF350標記的環指蛋白67抗體
別    名 NEURL; h neu; h neuralized 1; Neuralized homolog; Neuralized like protein 1; NEURL1; RING finger protein 67; RNF67; NEU1A_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  發育生物學  神經生物學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NEURL/RNF67
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
NEURL is involved in the determination of cell fate in the neurogenic region of the embryo and plays a role in the determination of cell fate in the central nervous system. NEURL may act as a tumor suppressor whose inactivation could be associated with malignant progression of astrocytic tumors.

Function:
May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway

Subcellular Location:
Cell membrane; Peripheral membrane protein. Cytoplasm, perinuclear region.

Tissue Specificity:
Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in an malignant astrocytomas and several neuroectodermal tumor cell lines.

Post-translational modifications:
Myristoylation is a determinant of membrane targeting

Similarity:
Contains 2 NHR (neuralized homology repeat) domains.
Contains 1 RING-type zinc finger.

Database links:

Entrez Gene: 9148 Human

Omim: 603804 Human

SwissProt: O76050 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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