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Rabbit Anti-TMEM132A/BF488 Conjugated antibody (bs-12068R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12068R-BF488
英文名稱 Rabbit Anti-TMEM132A/BF488 Conjugated antibody
中文名稱 BF488標記的跨膜蛋白132A抗體
別    名 GBP; HSPA5-binding protein 1; HSPA5BP1; T132A_HUMAN; Tmem132a; Transmembrane protein 132A.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 神經生物學  細胞凋亡  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 106kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TMEM132A
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
TMEM132A is a 560 amino acid protein encoded by a gene mapping to human chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and ∫ thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.

Function:
May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation.

Subunit:
Interacts with HSPA5/GRP78

Subcellular Location:
Golgi apparatus membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type I membrane protein

Similarity:
Belongs to the TMEM132 family.

Database links:

Entrez Gene: 540137 Cow

Entrez Gene: 612353 Dog

Entrez Gene: 100062008 Horse

Entrez Gene: 54972 Human

Entrez Gene: 98170 Mouse

Entrez Gene: 100511308 Pig

Entrez Gene: 338474 Rat

SwissProt: Q24JP5 Human

SwissProt: Q922P8 Mouse

SwissProt: Q80WF4 Rat

Unigene: 118552 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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