97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
中国一区二区视频,少妇特黄A片一区二区三区,99re热这里只有精品视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-CIITA/Gold Conjugated antibody (bs-13953R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-13953R-Gold
英文名稱 Rabbit Anti-CIITA/Gold Conjugated antibody
中文名稱 膠體金標記的組織相容性復合體蛋白2反式激活因子抗體
別    名 C2TA; C2TA_HUMAN; CIITA; Ciita; CIITA IV; class II major histocompatibility complex transactivator; class II transactivator; MHC class II transactivator; MHC class II transactivator type III; MHC2TA; NLR family acid domain containing; NLRA; Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  神經生物學  轉錄調節因子  淋巴細胞  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 123kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CIITA
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008]

Function:
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter.

Subunit:
Interacts with ZXDA and ZXDC. Interacts with PML (isoform PML-2).

Subcellular Location:
Nucleus.

DISEASE:
Defects in CIITA are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.

Similarity:
Contains 4 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.

Database links:

Entrez Gene: 4261 Human

Omim: 600005 Human

SwissProt: P33076 Human

Unigene: 701991 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 91视频盛宴 | 亚洲精品一区二区另类图片 | 在线观看免费网页欧美成 | 国产a级淫片 | 欧美日本在线一区 | 国产国语农村妇女偷人视频 | 日本人一级片 | 中文字幕第25页 | 精品人伦一区二区三区蜜桃视频 | 日本美女黄网站 | 香港三级日本三级韩国三级 | 东京热亚洲精品中文一区 | 91九色性视频 | 国产精品毛片va一区二区 | 精品国产91九色蝌蚪 | 国产国产午夜福利视 | 美国精品一区二区 | 亚洲午夜精品久久久久久高潮 | 日本www免费视频网站在线观看 | 成人免费视频一区二区三区 | 788好吊妞视频gaocom | 狠狠爱天天干 | 最近最新中文免费字幕一 | 女人和拘做受全程看免费软件 | 亚洲第一香蕉视频 | 无码av一区在线观看免费 | 久久99精品久久久久久236 | 亚洲午夜精品一区二区三区 | 我老公的家庭教师 | 日本中出视频 | 黄色欧美日韩 | 国产AV无码专区亚洲AV毛网站 | 9191久久久久久久久久久 | 国产精品久久久久久免费一级 | 夜色资源站ye321mp4 | 亚洲国产精品毛片AV不卡在线 | 人妻系列综合第一页 | 无码区日韩特区永久免费系列 | 另类综合日韩欧美亚洲 | 偷窥xxxx盗摄国产 | 高H猛烈失禁潮喷A片在线观看 |