97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
超碰免费网站,妺妺窝人体色WWW聚色窝仙踪,女社长的秘密奴调教
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-CIITA/Cy5.5 Conjugated antibody (bs-13953R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-13953R-Cy5.5
英文名稱 Rabbit Anti-CIITA/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的組織相容性復合體蛋白2反式激活因子抗體
別    名 C2TA; C2TA_HUMAN; CIITA; Ciita; CIITA IV; class II major histocompatibility complex transactivator; class II transactivator; MHC class II transactivator; MHC class II transactivator type III; MHC2TA; NLR family acid domain containing; NLRA; Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  轉錄調節因子  淋巴細胞  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 123kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CIITA
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008]

Function:
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter.

Subunit:
Interacts with ZXDA and ZXDC. Interacts with PML (isoform PML-2).

Subcellular Location:
Nucleus.

DISEASE:
Defects in CIITA are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.

Similarity:
Contains 4 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.

Database links:

Entrez Gene: 4261 Human

Omim: 600005 Human

SwissProt: P33076 Human

Unigene: 701991 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 无码少妇一区二区三区 | 亚洲精品黑人 | 久久久久久久免费视频 | 国产香蕉97碰碰视频VA碰碰看 | 无码专区无码专区视频网址 | 91精品国产综合久久男男 | 国产日韩在线 | 一本久久精品一区二区 | 国产精品一区二区福利视频 | av免费网站在线 | 亚洲三区在线观看内射后入 | 国产青草| 欧美成人免费全部观看天天性色 | 两性毛片 | 亚洲大香线伊人婷婷五月 | 天堂色影院 | 91一区| 亚洲国产成人精品无码区在线网站 | 日本孕妇潮喷高潮视频 | 日韩欧美成人一区二区三区 | 内射人妻视频国内 | 久久精品免费看 | 女人和拘做受全程看免费软件 | 亚洲男人的天堂在线 | 永久亚洲成a人片777777 | 亚洲成人av免费观看 | 日韩a级作爱片一二三区免费观看 | 欧美日韩免费专区在线 | 天天色综合合 | 国内精品久久久久精品 | 亚洲另类第一页 | 日韩在线 | 蜜桃av在线| 最刺激的毛片无遮挡欧美 | 永久亚洲成a人片777777 | 爆乳情帝国网综合社区 | 免费看av毛片多人群伦 | 日韩亚洲欧美在线 | 337p日本欧洲亚洲 | 亚洲午夜福利在线观看老司机 | 无码区日韩特区永久免费系列 |