97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
九九在线精品,欧洲美女乱xxoo高潮大片,极品毛片
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-CIITA/BF488 Conjugated antibody (bs-13953R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-13953R-BF488
英文名稱 Rabbit Anti-CIITA/BF488 Conjugated antibody
中文名稱 BF488標記的組織相容性復合體蛋白2反式激活因子抗體
別    名 C2TA; C2TA_HUMAN; CIITA; Ciita; CIITA IV; class II major histocompatibility complex transactivator; class II transactivator; MHC class II transactivator; MHC class II transactivator type III; MHC2TA; NLR family acid domain containing; NLRA; Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  轉錄調節因子  淋巴細胞  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 123kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CIITA
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008]

Function:
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter.

Subunit:
Interacts with ZXDA and ZXDC. Interacts with PML (isoform PML-2).

Subcellular Location:
Nucleus.

DISEASE:
Defects in CIITA are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.

Similarity:
Contains 4 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.

Database links:

Entrez Gene: 4261 Human

Omim: 600005 Human

SwissProt: P33076 Human

Unigene: 701991 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 啦啦啦资源视频在线完整免费高清 | 亚洲成人诱惑 | 欧美亚洲另类在线观看 | 黑人巨大精品欧美一区二区一 | 亚洲精品无码精品MV在线观看 | 无套内谢少妇毛片aaaa片免费 | 69爱爱视频 | 9久9久女女热精品视频在线观看 | 911久久香蕉国产线看观看 | 最新视频-x88av | 精品少妇XXXX | x88av入口av在线 | 国产毛片毛片毛片毛片毛片 | 97在线视频人妻无码 | 久久综合之合合综合久久 | 一区二区三区资源 | 国产精品免费人成网站 | 欧美亚洲日韩不卡在线在线观看 | 久久精品一区二区三区四区 | 97久久人人爽人人爽人人片 | 中文字幕之中文字幕 | 人人澡人人曰人人摸看 | 亚洲黄色在线免费观看 | 国产大奶在线 | 东京热亚洲精品中文一区 | 99久久精品免费看国产 | 亚洲免费黄色片 | 91人人精品 | 扒开双腿猛进入喷水高潮叫声 | 大地资源在线观看免费高清动漫 | 欧美一性一交一A片费看 | 18日本xxxxxxxxx95| 九色成人在线 | 天天干天天插天天 | 青青草久草在线视频 | 男人天堂亚洲成人 | 欧美40老熟妇色xxxxx | 色视频在线免费 | 免费观看18禁无遮挡真人网站 | 夜夜高潮夜夜爽夜夜爱爱一区 | 日韩一区二区三区在线播放 |