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Mouse Anti-CEA/BF647 Conjugated antibody (bsm-4792M-BF647)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bsm-4792M-BF647
英文名稱(chēng) Mouse Anti-CEA/BF647 Conjugated antibody
中文名稱(chēng) BF647標(biāo)記的癌胚抗原抗體
別    名 Carcino Embryonic Antigen CEA; CEACAM 5; CEACAM-5; Carcinoembryonic antigen; Carcinoembryonic antigen related cell adhesion molecule 5; CD66e; CD66e antigen; CEA; CEACAM5; DKFZp781M2392; Meconium antigen 100.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  干細(xì)胞  腫瘤細(xì)胞生物標(biāo)志物  
抗體來(lái)源 Mouse
克隆類(lèi)型 Monoclonal
克 隆 號(hào) 4F3
交叉反應(yīng) (predicted: Human, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 150-200kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CEA/CD66e/CEACAM5
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.

Function:
Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.

Subunit:
Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor

Tissue Specificity:
Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

Similarity:
Belongs to the immunoglobulin superfamily. CEA family.
Contains 7 Ig-like (immunoglobulin-like) domains.

Database links:

Entrez Gene: 1048 Human

Omim: 114890 Human

SwissProt: P06731 Human

Unigene: 709196 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CEA是一種胚胎性抗原,主要存在于胎兒消化道上皮組織,胰腺和肝癌中。CEA廣泛存在各種上皮性腫瘤,尤其是胃腸道惡性腫瘤,CEA分布陽(yáng)性類(lèi)型與腫瘤的惡性度有關(guān)。CEA與EMA一樣可作為上皮性惡性腫瘤的重要標(biāo)記。
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