97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
在线观看a级,上海黄金交易所每日行情,午夜妇女AAAA区片
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-COP1 (Ser387)/Biotin Conjugated antibody (bs-13976R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-13976R-Bio
英文名稱 Rabbit Anti-phospho-COP1 (Ser387)/Biotin Conjugated antibody
中文名稱 生物素標記的磷酸化E3泛素蛋白連接酶COP1抗體
別    名 COP1 (phospho S387); p-COP1 (phospho S387); Constitutive photomorphogenesis protein 1 homolog; COP; E3 ubiquitin-protein ligase RFWD2; hCOP1; RFWD2; RFWD2_HUMAN; RNF200; ring finger and WD repeat domain 2; RING finger and WD repeat domain protein 2; RING finger protein 200.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 信號轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human COP1 around the phosphorylation site of Ser387
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
COP1 is an E3 ubiquitin ligase protein that mediates ubiquitination and degradation of target proteins such as c-Jun and p53. It is a component of the DCX DET1-COP1 ubiquitin ligase complex which consists of RBX1, DET1, DDB1, CUL4A and COP1. Localizing to the cytoplasm and to the nucleus, COP1 is primarily expressed in testis, placenta, heart and skeletal muscle. COP1 is a potent inhibitor of p53-dependent transcription and apoptosis but, when phosphorylated by Atm (ataxia telangiectasia mutated) in response to DNA damage, the COP1-p53 complex is disrupted and p53 is allowed to exert its pro-apoptotic properties. In ovarian and breast cancers, COP1 is overexpressed, suggesting a role for COP1 in tumorigenesis.

Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.

Subcellular Location:
Nucleus speckle. Cytoplasm. In the nucleus, it forms nuclear speckles.

Tissue Specificity:
Ubiquitously expressed at low level. Expressed at higher level in testis, placenta, skeletal muscle and heart.

Similarity:
Belongs to the COP1 family.
Contains 1 RING-type zinc finger.
Contains 7 WD repeats.

Database links:

Entrez Gene: 64326 Human

Entrez Gene: 26374 Mouse

Omim: 608067 Human

SwissProt: Q8NHY2 Human

SwissProt: Q9R1A8 Mouse

Unigene: 523744 Human

Unigene: 328135 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 日本一区二区免费在线播放 | 国产又粗又黄又爽又硬的软件 | 爽爽午夜影视窝窝看片 | 成本人在线观看视频网站 | 久草在线观看首页 | 精品国产乱码一区二区三区99 | 久久精品中文字幕一区二区三区 | 日本亚洲网站 | 欧美日韩国产va另类 | 大地资源在线观看免费高清官网 | 久久久精品一区二区毛片免费看 | 91色在线视频 | 久久久久久国产精品免费免费狐狸 | 无码AV免费一区二区三区四区 | 清纯唯美经典一区二区 | 色国产视频 | 性色av一区二区怡红 | 亚洲综合成人婷婷五月在线观看 | 精品国产99久久久久久 | xxxx精品| 综合欧美亚洲日本 | 亚洲第一成人久久网站 | 国语国产精精品国产国语清晰对话 | 无码aⅴ免费中文字幕久久 国产精品1234 | 日本理论中文字幕 | 一区二区视频免费看 | 大地资源在线观看免费高清动漫 | 免费人成无码大片在线观看 | 无码专区—VA亚洲V天堂 | 国产91免费视频 | 亚洲精品无码永久在线观看性色 | 亚洲首页在线 | 日本黄色免费片 | 337p日本欧洲亚洲大胆艺术图 | www久久| 亚洲一卡2卡3卡4卡精品 | 国产成人一区二区在线观看 | 四虎影视在线影院在线观看 | 白虎视频污 | 变形金刚之超能勇士免费观看 | 国产色婷婷五月精品综合在线 |