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Rabbit Anti-SCUBE3/AP Conjugated antibody (bs-12317R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-12317R-AP
英文名稱 Rabbit Anti-SCUBE3/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的新型分泌細(xì)胞表面蛋白/成骨細(xì)胞相關(guān)蛋白SCUBE3抗體
別    名 CEGF3; CUB and EGF containing protein 3; CUB and EGF-like domain-containing protein 3; CUB domain and EGF like repeat containing 3; DKFZp686B09105; DKFZp686B1223; DKFZp686D20108; FLJ34743; OTTHUMP00000016250; SCUB3_HUMAN; SCUBE 3; SCUBE3; Signal peptide; Signal peptide CUB and EGF like domain containing protein 3; Signal peptide CUB domain EGF like 3.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 發(fā)育生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 107kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human SCUBE3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
SCUBE3 is a novel secreted 993 amino acid cell-surface osteoblast protein that plays an important role in bone cell biology. While highly expressed in osteoblasts, SCUBE3 expression is unobservable or very low in non-bone tissues. SCUBE3 forms homo-oligomers and hetero-oligomers with SCUBE1, and may undergo C-terminal proteolytic cleavage or become N-glycosylated following translation. Two SCUBE3 isoforms exist as a result of alternative splicing events. SCUBE3 contains one CUB domain and nine EGF-like domains, and is encoded by a gene which maps to human chromosome 6p21.31, a region associated with a rare form of metabolic bone disease known as Paget's disease. Chromosome 6 contains 170 million base pairs and comprises nearly 6% of the human genome.

Function:
Binds to TGFBR2 and activates TGFB signaling. In lungcancer cells, could serve as an endogenous autocrine and paracrineligand of TGFBR2, which could regulate TGFBR2 signaling and hencemodulate epithelial-mesenchymal transition and cancer progression.

Subunit:
Forms homooligomers and heterooligomers with SCUBE1.Interacts with TGFBR2 through the CUB domain; this interaction doesnot affect TGFB1-binding to TGFBR2.

Subcellular Location:
Secreted. Cell surface.

Tissue Specificity:
Highly expressed in osteoblasts. Expression is low or absent in non-bone tissues.

Post-translational modifications:
N-glycosylated.
May undergo proteolytic cleavage in the C-terminal region.

Similarity:
Contains 1 CUB domain.
Contains 9 EGF-like domains.

Database links:

Entrez Gene: 222663 Human

Entrez Gene: 268935 Mouse

Omim: 614708 Human

SwissProt: Q8IX30 Human

SwissProt: Q66PY1 Mouse

Unigene: 12923 Human

Unigene: 258491 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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