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Rabbit Anti-VNN2/Gold Conjugated antibody (bs-12340R-Gold)
訂購熱線:400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-12340R-Gold
英文名稱 Rabbit Anti-VNN2/Gold Conjugated antibody
中文名稱 膠體金標記的血管非炎性蛋白2抗體
別    名 FOAP 4; FOAP-4; Glycosylphosphatidyl inositol-anchored protein GPI-80; GPI 80; GPI-80; OTTHUMP00000017228; OTTHUMP00000233789; OTTHUMP00000233791; pantetheinase; Protein FOAP-4; vanin 2; Vanin-2; Vannin 2; Vascular non-inflammatory molecule 2; VNN2_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  心血管  發育生物學  干細胞  細胞粘附分子  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human VNN2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Vanin-2 is a 520 amino acid GPI-anchor protein that belongs to the CN hydrolase family and BTD/VNN subfamily.Widely expressed with high expression in spleen and blood, vanin-2 is suggested to be involved in thymus homing of bone marrow cells, regulation of Integrin ∫2-mediated cell adhesion, and migration and motility of neutrophils. Vanin-2 exists as five alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 6q23.2.

Function:
This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Two transcript variants encoding different isoforms have been described for this gene.

Subcellular Location:
Cell Membrane; Lipid-anchor, GPI-anchor

Tissue Specificity:
Widely expressed with higher expression in spleen and blood.

Similarity:
Belongs to the CN hydrolase family. BTD/VNN subfamily.
Contains 1 CN hydrolase domain.

Database links:
UniProtKB/Swiss-Prot: O95498.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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