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Rabbit Anti-Kindlin 2/APC Conjugated antibody (bs-12371R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12371R-APC
英文名稱 Rabbit Anti-Kindlin 2/APC Conjugated antibody
中文名稱 APC標記的絲裂原誘導蛋白2抗體
別    名 FLJ34213; FLJ44462; UNC112; FERM2_HUMAN; Fermitin family homolog 2; Fermt2; KIND2; Kindlin-2; MIG-2; MIG2; Mitogen-inducible gene 2 protein; PH domain-containing family C member 1; Pleckstrin homology domain containing family C (with FERM domain) member 1; Pleckstrin homology domain-containing family C member 1; PLEKHC1; UNC112B.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  發育生物學  信號轉導  干細胞  細胞粘附分子  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Kindlin 2/MIG2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Mig-2 recruits migfilin to cell-matrix adhesions, while the interaction with filamin mediates the association of migfilin with actin filaments. Together, Mig-2, migfilin and filamin define a connection between cell matrix adhesions and the actin cytoskeleton and participate in the orchestration of actin assembly and cell shape modulation. Mig-2 expression is transcriptionally elevated in leiomyomas and could be involved in its hormone-mediated growth of leiomyomas of the uterus. Expression of Mig-2 is ubiquitous, and it is found in numerous tumor tissues.

Function:
Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites.

Subunit:
Interacts with FBLP1.

Subcellular Location:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Note=Within actin stress fibers at cell-ECM focal adhesion sites.

Tissue Specificity:
Ubiquitous. Found in numerous tumor tissues.

Similarity:
Belongs to the kindlin family.
Contains 1 FERM domain.
Contains 1 PH domain.

Database links:

Entrez Gene: 10979 Human

Entrez Gene: 218952 Mouse

Entrez Gene: 289992 Rat

Entrez Gene: 616981 Cow

Omim: 607746 Human

SwissProt: Q96AC1 Human

SwissProt: Q8CIB5 Mouse

Unigene: 509343 Human

Unigene: 210018 Mouse

Unigene: 7658 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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