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Rabbit Anti-HES7/Gold Conjugated antibody (bs-12353R-Gold)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-12353R-Gold
英文名稱 Rabbit Anti-HES7/Gold Conjugated antibody
中文名稱 膠體金標記的轉錄因子HES7抗體
別    名 bHLH factor Hes7; bHLHb37; Class B basic helix loop helix protein 37; Class B basic helix-loop-helix protein 37; hairy and enhancer of split 7; Hes7; HES7_HUMAN; hHes7; SCDO4; Transcription factor HES 7; Transcription factor HES-7.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  發育生物學  信號轉導  干細胞  轉錄調節因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human HES7
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
HES7 is a 225 amino acid transcriptional repressor protein. Localized to the nucleus, HES7 represses transcription of N box- and E box-containing promoters. HES7, along with family member HES1, is thought to cooperatively regulate somite formation in the presomitic mesoderm. HES7 may also be essential for coordinated somite segmentation by acting as a segmentation clock. HES7 contains one basic helix-loop-helix (bHLH) domain and one Orange domain. Mutations in HES7 have been found to cause spondylocostal dysostosis, an autosomal recessive disorder characterized by deformities of the chest and spine.

Function:
Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation.

Subunit:
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family (By similarity).

Subcellular Location:
Nucleus.

DISEASE:
Defects in HES7 are the cause of spondylocostal dysostosis type 4 (SCDO4) [MIM:613686]. A rare condition of variable severity characterized by vertebral and costal anomalies. The main feature include dwarfism, vertebral fusion, hemivertebrae, posterior rib fusion, reduced rib number, and other rib malformations.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 Orange domain.

Database links:
UniProtKB/Swiss-Prot: Q9BYE0.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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