97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
欧美精品羞羞答答,日日干日日插,大胆裸体gogo毛片免费看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-MEGF10/Cy5.5 Conjugated antibody (bs-12372R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12372R-Cy5.5
英文名稱 Rabbit Anti-MEGF10/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的表皮生長因子樣蛋白Megf10抗體
別    名 MEG10_HUMAN; MEGF protein; megf10; Multiple EGF-like domains protein 10; multiple EGF-like-domains 10; Multiple epidermal growth factor-like domains 10; Multiple epidermal growth factor-like domains protein 10.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  發育生物學  干細胞  細胞凋亡  生長因子和激素  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 119kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MEGF10
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
MEGF10 is a 1,140 amino acid protein encoded by the human gene MEGF10. MEGF10 belongs to the MEGF family and contains fifteen EGF-like domains and one EMI domain. The engulfment of dying cells is a specialized form of phagocytosis that is highly conserved across evolution and is mediated by the concerted action of several molecules. MEGF10 is an engulfment receptor protein that localizes to the plasma membrane in a punctuated pattern. The MEGF10 protein shares structural similarities with nematode engulfment receptor cell death abnormal-1 (CED-1). MEGF10 function is modulated by the ATP binding cassette transporter ABCA1, which is an ortholog to CED-7. It is expressed at the cell surface in clusters around cell corpses during engulfment, and during the engulfment of apoptotic thymocytes is recruited to the bottom of the forming phagocytic cup.

Function:
Involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 during engulfment. Destabilizes the oligomeric assemblies of the ABCA1 transporter. Plays a role in cell adhesion. Inhibits cell motility and cell proliferation in vitro. Promotes formation of large intracellular vacuoles.

Subunit:
Homopolymer (Probable). Interacts with GULP1 and ABCA1. Interacts with AP2M1. Does not interact with MEGF11.

Subcellular Location:
Cell membrane.

Post-translational modifications:
Phosphorylated on tyrosine residues.
Ubiquinated; mono- and polyubiquitinated forms are detected.

DISEASE:
Defects in MEGF10 are the cause of myopathy, early-onset, areflexia, respiratory distress, and dysphagia (EMARDD) [MIM:614399]. An autosomal recessive congenital myopathy characterized by onset at birth, or early in infancy, of respiratory distress caused by diaphragmatic weakness. Additional features are dysphagia resulting in poor feeding, failure to thrive, poor head control, facial weakness, cleft palate, contractures and scoliosis. Affected individuals become ventilator-dependent, and most require feeding by gastrostomy. The disorder results in severe muscle weakness and most patients never achieve walking. Death from respiratory failure in childhood occurs in about half of patients. Muscle biopsy shows myopathic changes, replacement of myofibers with fatty tissue, small and incompletely fused muscle fibers, and variation in fiber size. Short regions of sarcomeric disorganization with few or no mitochondria (minicores) have been observed in some cases.

Similarity:
Belongs to the MEGF family.
Contains 15 EGF-like domains.
Contains 1 EMI domain.

Database links:

Entrez Gene: 84466 Human

SwissProt: Q96KG7 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 久久WWW成人看片免费不卡 | 人妻丝袜AV中文系列先锋影音 | 亚洲欧美日韩精品久久 | 国产亚洲2021成人乱码 | 精品91在线视频 | 欧美一级大黄大黄大色毛片小说 | 男同男性xx视频在线观看免费 | 亚洲一级在线看 | 美丽姑娘免费高清观看 | 亚洲网站观看 | 国产九色网站 | 日本视频在线看 | 成全动漫在线观看免费高清 | 藏精阁成人免费观看在线视频 | 67194中文字幕在线观看日韩 | 22222se男人的天堂 | 国产超a级动作大片中文字幕 | 四虎av无码专区亚洲av | 精品一区二区三区四区蜜桃 | 久久激情网站 | 国产高潮A片一区二区 | 久久久噜噜噜久久熟女 | 俺去啦久久草在线视频 | 国产麻豆精品福利在线观看 | 在教室伦流澡到高潮H强圩动漫 | 国产欧美日韩在线观看一区二区 | 日本一区二区免费高清视频 | 色哟哟~日韩精品 | 日本十八禁视频无遮挡 | 国99精品无码一区二区三区 | 国产色噜噜噜91在线精品 | 国产精品视频色拍拍 | 国产网红主播精品一区二区三区 | 国产成人午夜性a一级毛片 涩涩久久久 | 白浆在线| 蜜桃精品视频 | 久久久青青草原 | 日韩视频一区尤物少妇偷拍 | 男人日女人逼的视频 | 日本中文字幕日韩精品免费 | 日本免费三级网站 |