97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
毛片免费小视频,日日爱夜夜操,亚洲天堂视频在线播放
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-MEGF10/PE-Cy3 Conjugated antibody (bs-12372R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12372R-PE-Cy3
英文名稱 Rabbit Anti-MEGF10/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的表皮生長因子樣蛋白Megf10抗體
別    名 MEG10_HUMAN; MEGF protein; megf10; Multiple EGF-like domains protein 10; multiple EGF-like-domains 10; Multiple epidermal growth factor-like domains 10; Multiple epidermal growth factor-like domains protein 10.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  發育生物學  干細胞  細胞凋亡  生長因子和激素  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 119kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MEGF10
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
MEGF10 is a 1,140 amino acid protein encoded by the human gene MEGF10. MEGF10 belongs to the MEGF family and contains fifteen EGF-like domains and one EMI domain. The engulfment of dying cells is a specialized form of phagocytosis that is highly conserved across evolution and is mediated by the concerted action of several molecules. MEGF10 is an engulfment receptor protein that localizes to the plasma membrane in a punctuated pattern. The MEGF10 protein shares structural similarities with nematode engulfment receptor cell death abnormal-1 (CED-1). MEGF10 function is modulated by the ATP binding cassette transporter ABCA1, which is an ortholog to CED-7. It is expressed at the cell surface in clusters around cell corpses during engulfment, and during the engulfment of apoptotic thymocytes is recruited to the bottom of the forming phagocytic cup.

Function:
Involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 during engulfment. Destabilizes the oligomeric assemblies of the ABCA1 transporter. Plays a role in cell adhesion. Inhibits cell motility and cell proliferation in vitro. Promotes formation of large intracellular vacuoles.

Subunit:
Homopolymer (Probable). Interacts with GULP1 and ABCA1. Interacts with AP2M1. Does not interact with MEGF11.

Subcellular Location:
Cell membrane.

Post-translational modifications:
Phosphorylated on tyrosine residues.
Ubiquinated; mono- and polyubiquitinated forms are detected.

DISEASE:
Defects in MEGF10 are the cause of myopathy, early-onset, areflexia, respiratory distress, and dysphagia (EMARDD) [MIM:614399]. An autosomal recessive congenital myopathy characterized by onset at birth, or early in infancy, of respiratory distress caused by diaphragmatic weakness. Additional features are dysphagia resulting in poor feeding, failure to thrive, poor head control, facial weakness, cleft palate, contractures and scoliosis. Affected individuals become ventilator-dependent, and most require feeding by gastrostomy. The disorder results in severe muscle weakness and most patients never achieve walking. Death from respiratory failure in childhood occurs in about half of patients. Muscle biopsy shows myopathic changes, replacement of myofibers with fatty tissue, small and incompletely fused muscle fibers, and variation in fiber size. Short regions of sarcomeric disorganization with few or no mitochondria (minicores) have been observed in some cases.

Similarity:
Belongs to the MEGF family.
Contains 15 EGF-like domains.
Contains 1 EMI domain.

Database links:

Entrez Gene: 84466 Human

SwissProt: Q96KG7 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲精品在线视频免费观看 | 狠狠综合久久久久综合 | 中文字幕在线观看不卡视频 | 亚洲精品成人网站在线 | 99久久国产综合精品女不卡 | 国产精品porn | 精品欧美不卡一区二区在线观看 | ipx亚洲一区二区三区 | 日本激情视频在线播放 | 天堂а在线最新版在线 | 欧美日韩在线影院 | 国产一二三区在线视频 | 伊人75在线 | 在线a毛片 | 人人超碰人人爱超碰国产 | 亚洲一片黄 | 国产成人综合日韩精品无码 | 天地争霸美猴王国语在线观看免费 | 中文字幕第25页 | 日本激情视频在线播放 | 日韩精品区一区二区三vr | 日韩毛片网站 | 久久日韩精品一区鲁大师 | 在线观看av网 | www中文字幕 | 黄色大片免费网址 | 一级黄色裸体片 | 亚洲日韩欧美一区久久久久我 | 青青草视频在线观 | 激情偷乱人伦小说视频在线精 | 永久免费无码网站在线观看 | 国产综合色在线视频 | 拍拍拍产国影院在线观看 | 91porny九色在线| 免费AV片在线观看蜜芽TV | 双飞两少妇国语对白 | 国产av一级毛片 | 888久久| 五十度灰2在线观看 | 白天躁晚上躁麻豆视频 | 欧美日韩国产人妻无码 |