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Rabbit Anti-AES/Gold Conjugated antibody (bs-12392R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-12392R-Gold
英文名稱 Rabbit Anti-AES/Gold Conjugated antibody
中文名稱 膠體金標記的gp130結合蛋白GAM抗體
別    名 Aes 1; Amino-terminal enhancer of split; Aes 2; aes; AES_HUMAN; Aes1; Aes2; Amino Enhancer of Split; Amino terminal enhancer of split; Amino-terminal enhancer of split; Esp 1; Esp1; Gp130 associated protein GAM; Gp130-associated protein GAM; GRG 5; GRG; GRG protein; GRG5; Protein ESP 1; Protein ESP1; Protein GRG; TLE 5; TLE5.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  信號轉導  干細胞  轉錄調節因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Cow, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TLE5/Amino-terminal enhancer of split
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
TLE5 is a 197 amino acid nuclear protein that belongs to the TLE family. Expressed predominately in fetal brain, liver, lung, heart and kidney and in adult muscle, TLE5 functions as either a homooligomer or a heterooligomer with other TLE family members and, through this association, dominantly represses the expression of TLE genes. In addition, TLE5 can repress NFkB-regulated gene expression and is thought to play an important role in initiating and maintaining cell differentiation events. Two isoforms of TLE5 exist due to alternative splicing events.

Function:
Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state.

Subunit:
Homooligomer and heterooligomer with other family members. Binds TCF7 (By similarity). Binds the NF-kappa-B subunit RELA. Interacts with PHF12.

Subcellular Location:
Nucleus.

Tissue Specificity:
Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.

Post-translational modifications:
Ubiquitinated by XIAP/BIRC4.

Similarity:
Belongs to the WD repeat Groucho/TLE family.

Database links:

Entrez Gene: 166 Human

Entrez Gene: 14797 Mouse

Entrez Gene: 29466 Rat

Omim: 600188 Human

SwissProt: Q08117 Human

SwissProt: P63002 Mouse

SwissProt: P63003 Rat

Unigene: 515053 Human

Unigene: 180013 Mouse

Unigene: 11495 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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