97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久久精品免费视频播放,精品国产乱码久久久久久a丨,91女同
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-MAML1/HRP Conjugated antibody (bs-12396R-HRP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12396R-HRP
英文名稱 Rabbit Anti-MAML1/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標記的主導控制樣蛋白1抗體
別    名 Mam-1; Mam1; MAML 1; MAML 1; Maml1; MAML1_HUMAN; Mastermind like 1; Mastermind-like protein 1; mKIAA0200.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  信號轉導  干細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Horse, )
產品應用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 108kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MAML1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs, and humans (1). The 'mastermind' gene has been identified in multiple genetic screens for modifiers of Notch mutations in Drosophila melanogaster (2). In Drosophila, loss-of-function mutations of Notch produce a 'neurogenic' phenotype in which cells destined to become epidermis switch fate and differentiate to neural cells (2). The human homolog, mastermind-like 1 (Mam1), localizes to nuclear bodies (2-4). Mam1 binds to the ankyrin repeat domain of all four mammalian Notch receptors, forms a DNA-binding complex with ICN and RBP-Jk, and amplifies Notch-induced transcription of Hes1 (2). Mam1 is an essential component of the transcriptional apparatus of Notch signaling (5). The gene which encodes Mam1 maps to human chromosome 5 (4).

Function:
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

Subunit:
Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8.

Subcellular Location:
Nucleus speckle. Nuclear, in a punctate manner.

Tissue Specificity:
Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.

Similarity:
Belongs to the mastermind family.

Database links:
UniProtKB/Swiss-Prot: Q92585.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 久久免费播放视频 | 天堂久久一区二区三区 | 国产精品啊啊啊 | 在线欧美鲁香蕉94色 | 国产亚洲AV人片在线观看 | 国产一区二区三区不卡在线看 | 男人天堂免费视频 | 久久久av免费 | 亚洲最新无码中文字幕久久 | 欧美日韩成人在线视频 | 国产萌白酱喷水视频在线观看 | 一道本不卡视频 | 成年日韩片AV在线网站医生 | 99久RE热视频这里只有精品6 | 色视频网站在线观看 | 国产成人一区二 | 亚洲中文字幕无码久久2017 | 国产老女人乱淫免费 | 亚色中文 | 欧美日韩在线视频 | 伊人久久大香线蕉AV五月天宝贝 | 翁吻乳婷婷小玲21 | 国产网站在线看 | 人人99精 | 亚洲国产精品一区二区尤物区 | 国产又黄又硬又粗 | xxx.在线观看 | 国产日本亚洲欧美 | 欧美黑人欧美精品刺激 | 斗罗大陆3龙王传说第四季免费观看 | 理论片中文字幕 | 麻豆最新国产剧情AV原创 | 好看的国产精品视频 | 麻豆av传媒 | 特黄色一级片 | 欧美性福| 成人免费无码大片A毛片 | 国产欧美日韩综合 | 精品国产入口麻豆 | 国产最顶级的黄色片在线免费观看 | 国产激情网站 |