97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久久99久国产麻精品66,国产粉嫩在线,国产乱码精品一区二区三区中文
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-MAML1/Gold Conjugated antibody (bs-12396R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-12396R-Gold
英文名稱 Rabbit Anti-MAML1/Gold Conjugated antibody
中文名稱 膠體金標記的主導控制樣蛋白1抗體
別    名 Mam-1; Mam1; MAML 1; MAML 1; Maml1; MAML1_HUMAN; Mastermind like 1; Mastermind-like protein 1; mKIAA0200.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  神經生物學  信號轉導  干細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Horse, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 108kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MAML1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs, and humans (1). The 'mastermind' gene has been identified in multiple genetic screens for modifiers of Notch mutations in Drosophila melanogaster (2). In Drosophila, loss-of-function mutations of Notch produce a 'neurogenic' phenotype in which cells destined to become epidermis switch fate and differentiate to neural cells (2). The human homolog, mastermind-like 1 (Mam1), localizes to nuclear bodies (2-4). Mam1 binds to the ankyrin repeat domain of all four mammalian Notch receptors, forms a DNA-binding complex with ICN and RBP-Jk, and amplifies Notch-induced transcription of Hes1 (2). Mam1 is an essential component of the transcriptional apparatus of Notch signaling (5). The gene which encodes Mam1 maps to human chromosome 5 (4).

Function:
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

Subunit:
Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8.

Subcellular Location:
Nucleus speckle. Nuclear, in a punctate manner.

Tissue Specificity:
Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.

Similarity:
Belongs to the mastermind family.

Database links:
UniProtKB/Swiss-Prot: Q92585.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 欧美高清视频 | 91精品爽啪蜜夜国产在线播放 | 免费播放av | av在线免费播放不卡 | 澳门黄色网 | 台湾绝版午夜裸体写真秀 | 综合欧美亚洲日本 | 亚洲网站三级 | 国产亚洲精品久久久一区 | 国产视频久久网 | 亚洲性高清SUV | 韩国激情高潮无遮挡hd | 亚洲国产精品成人女人久久久 | 蜜桃天堂| 午夜精品成人一区二区 | 亚洲成av人在线看 | 国产日韩欧美一区二区三区乱码 | 久久亚洲sm情趣捆绑调教 | 日韩色网站| 久久99久| 国产精品久久久久久久久久新婚 | 97人妻人人做人碰人人添 | 天天夜操 | 国产精品一区二区三区成人 | 二区在线观看 | 日本JAPANESE丰满多毛 | 国产精品美女视频 | 99热精品只有这里有 | 国产麻豆老师在线观看 | 日韩高清在线观看 | 欧美亚洲国产精品久久高清 | 熟妇人妻AV中文字幕老熟妇 | 久久中文字幕一区二区三区 | 扒开双腿吃奶呻吟做受 | 久久久精品一区二区三区 | 黄色毛片a级片 | 免费不卡欧美自拍视频 | 免费观看一区二区三区毛片 | ts国产人妖视频在线观看 | 亚洲37p| 人妻仑乱a级毛片免费看 |