97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
善良的表妹hd2,久久av福利,老司机午夜免费视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-MAML1/BF488 Conjugated antibody (bs-12396R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12396R-BF488
英文名稱 Rabbit Anti-MAML1/BF488 Conjugated antibody
中文名稱 BF488標記的主導控制樣蛋白1抗體
別    名 Mam-1; Mam1; MAML 1; MAML 1; Maml1; MAML1_HUMAN; Mastermind like 1; Mastermind-like protein 1; mKIAA0200.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  信號轉導  干細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Horse, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 108kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MAML1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs, and humans (1). The 'mastermind' gene has been identified in multiple genetic screens for modifiers of Notch mutations in Drosophila melanogaster (2). In Drosophila, loss-of-function mutations of Notch produce a 'neurogenic' phenotype in which cells destined to become epidermis switch fate and differentiate to neural cells (2). The human homolog, mastermind-like 1 (Mam1), localizes to nuclear bodies (2-4). Mam1 binds to the ankyrin repeat domain of all four mammalian Notch receptors, forms a DNA-binding complex with ICN and RBP-Jk, and amplifies Notch-induced transcription of Hes1 (2). Mam1 is an essential component of the transcriptional apparatus of Notch signaling (5). The gene which encodes Mam1 maps to human chromosome 5 (4).

Function:
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

Subunit:
Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8.

Subcellular Location:
Nucleus speckle. Nuclear, in a punctate manner.

Tissue Specificity:
Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.

Similarity:
Belongs to the mastermind family.

Database links:
UniProtKB/Swiss-Prot: Q92585.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 男人添女人下身视频高清 | 狠狠插天天干 | 日本高清一二区 | 亚洲不卡在线视频 | 久久情侣视频 | 橘梨纱av一区二区三区在线观看 | 亚洲天堂中文 | H无码精品动漫在线观看导航 | 野花社区www官网在线观看 | 日日爱668| 日韩欧美在线观看视频 | 精品精品国产高清a毛片 | 精品毛片 | 麻豆av一区二区三区久久 | 蜜臀亚洲AV无码精品国产午夜. | 黄瓜视频入口永久免费观看 | 国产一及毛片 | 日日摸夜夜添夜夜添无码免费视频 | 久久久国产日韩 | 久久精品欧美一区二区三区不卡 | 国产成在线观看免费视频成本人 | 亚洲日韩爆乳中文字幕欧美 | 亚洲a一区二区三区 | 91精品国| 产精品视频在线观看免费 | 国产精品毛片av999999 | 国产九色sp调教91 | 亚洲精品视频大全 | 扒开双腿猛进入喷水高潮叫声 | 欧美国产三级 | 韩日中文字幕 | 91九色性视频 | 国产精品极品美女自在线观看免费 | 色欲色欲天天天WWW亚洲伊 | 欧美日韩国产综合视频 | 亚洲AV无码精品色午夜蜜芽 | 中文字幕视频6区 | 蜜桃视频网站在线观看 | 日韩欧美中文字幕在线四区 | 午夜理理伦A级毛片天天看 一区视频免费观看 | 毛片视频软件 |