97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久久影院国产精品,五月天堂网,韩国理论在线观看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-Kir6.2 (Thr224)/BF350 Conjugated antibody (bs-12181R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12181R-BF350
英文名稱 Rabbit Anti-phospho-Kir6.2 (Thr224)/BF350 Conjugated antibody
中文名稱 BF350標記的磷酸化ATP敏感性鉀通道亞基kir6.2抗體
別    名 Kir6.2 (phospho T224); ATP sensitive inward rectifier potassium channel 11; Beta cell inward rectifier subunit; mBIR; BIR; HHF 2; HHF2; IKATP; Inward rectifier K(+) channel Kir6.2; Inwardly rectifying potassium channel KIR6.2; IRK 11; IRK11; KCNJ11; Kir 6.2; Kir6.2; MGC133230; PHHI; Potassium channel, inwardly rectifying subfamily J member 11; Potassium inwardly rectifying channel J11; TNDM 3; TNDM3.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  心血管  細胞生物  信號轉導  轉錄調節因子  通道蛋白  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Kir6.2 around the phosphorylation site of Thr224
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]

Function:
ATP-sensitive potassium (K(ATP)) channels are found in endocrine cells, neurons and both smooth and striated muscle, where they play an important role in controlling insulin secretion and vascular tone, and protect neurons under metabolic stress. Kir6.2 is a member of the inward rectifier potassium channel family, which is characterised by a greater tendency to allow potassium flow into the cell rather than out of it. It associates with the sulphonylurea receptor SUR1/ABCC8 to form a subfamily of K(ATP) channels that, when mutated or misregulated, are associated with forms of hyperinsulinemic hypoglycemia, neonatal diabetes, or pre-disposition to type 2 diabetes mellitus.

Subunit:
Interacts with ABCC8/SUR. Interacts with ABCC9/SUR2.

Subcellular Location:
Cell Membrane; Multi-pass membrane protein

DISEASE:
Defects in KCNJ11 are the cause of familial hyperinsulinemic hypoglycemia type 2 (HHF2) [MIM:601820]; also known as persistent hyperinsulinemic hypoglycemia of infancy (PPHI) or congenital hyperinsulinism. HHF is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. It causes nesidioblastosis, a diffuse abnormality of the pancreas in which there is extensive, often disorganized formation of new islets. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur.
Defects in KCNJ11 are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
Defects in KCNJ11 are the cause of transient neonatal diabetes mellitus type 3 (TNDM3) [MIM:610582]. Neonatal diabetes mellitus, defined as insulin-requiring hyperglycemia within the first month of life, is a rare entity. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. In a significant number of patients with transient neonatal diabetes mellitus, diabetes type 2 appears later in life. The onset and severity of TNDM3 is variable with childhood-onset diabetes, gestational diabetes or adult-onset diabetes described.
Note=Defects in KCNJ11 may contribute to non-insulin-dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type 2.

Similarity:
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.

Database links:

Entrez Gene: 3767 Human

Entrez Gene: 16514 Mouse

Omim: 600937 Human

SwissProt: Q14654 Human

SwissProt: Q61743 Mouse

Unigene: 248141 Human

Unigene: 333863 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产色视频在线播放 | 99久久免费看精品国产一区 | 久久夜色精品国产欧美 | 夜色阁亚洲一区二区三区 | 天天操天天干天天爽 | 国产精品一区二区免费久久精品 | 少妇在宾馆高潮不断狂叫床 | 成人免费视频一区二区三区 | 国产精品一区自拍 | 熟女人妻aⅴ一区二区三区60路 | 亚洲精品一区二区成人 | 毛片18| 亚洲国产精品ⅴa在线观看 天天看逼 | 亚洲VS成人无码人在线观看堂 | 国产高中美女福利剧情简介 | 亚人在线播放国产中文字幕 | 99精品一级欧美片免费播放资讯 | 成人一区二区三区在线观看 | 色婷婷五月综合激情中文字幕 | 国产欧美一区二区白浆黑人 | 无码日韩精品一区二区免费 | 国内精品久久久人妻中文字幕 | 欧洲区乱码一二三 | 35日本xxxxxxxxx25 欧美人与禽猛交乱配视频 丰满老熟女毛片hd 欧美粗大无套gay | 日本不卡一区二区三区四区 | 国产在线乱码一区二三区 | 亚洲国产成人精品女人久 | 色婷婷在线精品国自产拍 | 操的很爽 | 天天舔夜夜 | 日韩欧美人妻一区二区三区 | 波多野结衣在线视频一区二区三区 | 亚洲欧洲成人在线 | 一二三四中文在线 | 日本一区精品 | 久久久久久久波多野结衣高潮 | 精品福利视频一区二区三区 | 成人羞羞网站 | 国产高清一级毛片在线不卡 | 四虎看黄 | 91老司机福利 |