97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
强奷高H猛烈失禁潮喷播放,免费毛片av,精品国产亚洲一区二区三区在线观看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-CK18(Ser52)/Cy5.5 Conjugated antibody (bs-12921R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12921R-Cy5.5
英文名稱 Rabbit Anti-phospho-CK18(Ser52)/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的磷酸化細胞角蛋白18抗體
別    名 Cytokeratin 18 (phospho S52); p-Cytokeratin 18 (phospho S52); Cell proliferation inducing gene 46 protein; Cell proliferation inducing protein 46; Cell proliferation-inducing gene 46 protein; CK 18; CK-18; CK18; CYK 18; CYK18; Cytokeratin 18; Cytokeratin endo B; Cytokeratin-18; Cytokeratin18; K 18; K18; K1C18_HUMAN; Keratin 18; Keratin D; Keratin type I cytoskeletal 18; keratin, type I cytoskeletal 18; Keratin-18; Keratin18; Kerd; KRT18.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat, 
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from mouse CK18 around the phosphorylation site of Ser52 [SR(p-S)VW]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].

Function:
When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Subunit:
Heterotetramer of two type I and two type II keratins. KRT18 associates with KRT8. Interacts with the thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD.

Subcellular Location:
Cytoplasm, perinuclear region. Nucleus, nucleolus.

Tissue Specificity:
Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

Post-translational modifications:
Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.
O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.

DISEASE:
Defects in KRT18 are a cause of cirrhosis (CIRRH) [MIM:215600].

Similarity:
Belongs to the intermediate filament family.

Database links:

Entrez Gene: 506480 Cow

Entrez Gene: 3875 Human

Entrez Gene: 16668 Mouse

Entrez Gene: 294853 Rat

Omim: 148070 Human

SwissProt: P05783 Human

SwissProt: P05784 Mouse

SwissProt: Q5BJY9 Rat

Unigene: 406013 Human

Unigene: 22479 Mouse

Unigene: 103924 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 欧美一区二区三区蜜桃 | 人人爽在线视频 | 成人AV片无码免费网站 | 夜夜高潮夜夜爽夜夜爱爱一区 | 99热精品只有这里有 | 九月婷婷 | 97色在线视频 | 日本少妇激三级做爰在线 | 久久精品一级爱片 | 一级毛片免费一级 | av影视网 | 女人18毛片a级毛片免费视频 | 亚洲欧美日韩国产自偷 | 91精品国产乱码久久久软件 | 国产精品免费自拍 | 55夜色66夜色国产精品视频 | 亚洲国产亚洲 | 毛片18 | 九九99无码精品视频在线观看 | 俄罗斯小younv另类 | 亚洲国产精品一区二区尤物区 | 天天干夜夜爽 | 国产精品538一区二区在线 | 亚洲精品日本无v一区 | 波多野结衣在线视频一区二区三区 | 亚洲精品无码久久久久AV老牛 | 91老司机福利在线视频 | 孕妇奶水仑乱A级毛片免费看 | 亚洲国产中文字幕 | 性欧美视频一区二区三区 | 欧美一个色资源 | 麻豆国产手机福利看片 | av网站免费在线播放 | 黄色免费日本 | 国产在线精品一区二区在线看 | youjazz性欧美 | 免费看日产一区二区三区 | 女人和拘做受全程看免费软件 | 橘梨纱av一区二区三区在线观看 | 亚洲精品7777 | 亚洲涩涩av|