97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
精品国产91aⅴ一区二区三区,午夜日韩欧美,欧美日韩在线激情
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-FMRP (Ser500)/AP Conjugated antibody (bs-13188R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-13188R-AP
英文名稱 Rabbit Anti-phospho-FMRP (Ser500)/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的磷酸化脆性X綜合征相關蛋白AFF1抗體
別    名 FMRP (phospho S500); FMRP (phospho Ser500); p-FMRP (phospho S500); p-FMR1 (phospho S500); FMR1; FMR1_HUMAN; FMRP; FMRP phospho S499; Fragile X mental retardation 1; Fragile X mental retardation 1 protein; Fragile X mental retardation protein 1; FRAXA; MGC87458; POF; POF1; Protein FMR-1; Protein FMR1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 細胞生物  神經生物學  信號轉導  細胞類型標志物  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Rabbit, Zebrafish, Sheep, Guinea Pig, Danio rerio)
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 75kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human FMRP around the phosphorylation site of Ser500
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
?Fragile X syndrome is the most frequent form of inherited mental retardation and is the result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 gene contains a distinct CpG dinucleotide repeat located in the 5' untranslated region of the gene. In fragile X syndrome this tandem repeat is substantially amplified and subjected to extensive methylation and enhanced transcriptional silencing. The FMR1 protein (or FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. It contains several features that are characteristics of RNA-binding proteins, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box). FMR1 localizes to both the nucleus and the cytoplasm and can also interact with two fragile X syndrome related factors, FXR1 and FXR2, which form heterodimers through their N-terminal coiled-coil domains. Since FMR1 contains both a nuclear localization signal and a nuclear export signal it is also implicated in the nucleocytoplasmic transport of mRNAs.

Function:
Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).

Subunit:
Component of the CYFIP1-EIF4E-FMR1 complex which is composed of CYFIP, EIF4E and FMR1. Interacts with CYFIP1 and CYFIP2. The interaction with brain cytoplasmic RNA 1 (BC1) increases binding affinity for the CYFIP1-EIF4E complex in the brain (By similarity). Homooligomer. Found in a RNP granule complex with IGF2BP1. Directly interacts with SMN and TDRD3. Interacts with the SMN core complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts with FXR1, FXR2, IGF2BP1, NUFIP1, NUFIP2, MCRS1 and RANBP9.

Subcellular Location:
Cytoplasm. Nucleus, nucleolus.

Tissue Specificity:
Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells.

Post-translational modifications:
Phosphorylated on several serine residues.

DISEASE:
Defects in FMR1 are the cause of fragile X syndrome (FRAX) [MIM:300624]. Fragile X syndrome is a common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.
Defects in FMR1 are the cause of fragile X tremor/ataxia syndrome (FXTAS) [MIM:300623]. In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as 'premutations'. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:300624]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems.
Defects in FMR1 are the cause of premature ovarian failure syndrome type 1 (POF1) [MIM:311360]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.

Similarity:
Belongs to the FMR1 family.
Contains 2 Agenet-like domains.
Contains 2 KH domains.

Database links:
UniProtKB/Swiss-Prot: Q06787.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 欧美一区二区三区少妇 | 青青草青娱乐在线 | 亚洲av网址在线观看 | 92国产精品偷窥熟女精品视频 | 无码熟妇人妻AV在线网站 | 8x成人网| 亚洲乱色熟女一区二区三区 | 国产成年无码久久久免费 | 北条麻妃在线播放 | 67PAO国产成视频永久免费 | 成人国产精品一区 | 精品久久免费 | 亚洲日韩一区精品射精 | avtt久久| 午夜视频老司机 | 性欧美一区二区 | 欧美一级大黄大黄大色毛片小说 | www.久久视频| 久久久久久无码AV成人影院 | 国产亚洲欧美日韩高清 | 日韩第一夜| 在线观看91精品国产入口 | 99视频国产精品免费观看 | a久久免费视频 | 高H猛烈失禁潮喷A片在线观看 | 九热在线 | 国产精品无码一区二区三区不卡 | 国产一区二区视频在线看 | 少妇大胆瓣开下部自慰 | 网站久久久| 999视频精品| 中文无码一区二区视频在线播放 | 国产伦精品一区二区三区网站 | 日韩精品一区二区三区中文无码 | 日本一区视频在线观看 | 无人高清视频免费观看在线 | 99re免费视频精品全部 | 1024在线观看国产天堂 | 999久久久国产精品消防器材 | 无码人妻丰满熟妇区a?v | 国产一级淫片a按摩推澡按摩 |