97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
龙凤斗国语免费观看,北条麻妃精品久久中文字幕,av福利一区
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-Frizzled 6/PE Conjugated antibody (bs-13218R-PE)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-13218R-PE
英文名稱 Rabbit Anti-Frizzled 6/PE Conjugated antibody
中文名稱 PE標記的卷曲蛋白6抗體
別    名 Frizzled 6 seven transmembrane spanning receptor; Frizzled drosophila homolog of 6; Frizzled family receptor 6; Frizzled homolog 6 (Drosophila); Frizzled homolog 6; Frizzled-6; Frizzled6; Fz 6; Fz-6; Fz6; FZD 6; Fzd6; FZD6_HUMAN; Hfz 6; hFz6; NDNC10.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  發(fā)育生物學  信號轉(zhuǎn)導  干細胞  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 77kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Frizzled 5/Wnt receptor
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted mammalian frizzled-related proteins (FRPs), have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy-terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The frizzled-5 protein is believed to be the receptor for the Wnt-5A ligand. The cysteine-rich domain of frizzled-8 blocks endogenous Wnts and the effects of Wnt-1 and Wnt-5 on proliferation. The mouse frizzled-8 gene, which encodes a Wnt receptor, is a potent cancer-associated activator of the ∫-catenin-TCF pathway. The frizzled-8 gene contains no introns. Frizzled-8 mRNA has been detected in fetal brain and kidney, and also in adult pancreas, skeletal muscle, kidney and heart. Frizzled is highly expressed in HeLa S3 (cervical uterus cancer) cells and A549 lung cancer cells.

Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular Location:
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity).

Tissue Specificity:
Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.

Post-translational modifications:
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity).

DISEASE:
Defects in FZD6 are the cause of nail disorder non-syndromic congenital type 10 (NDNC10) [MIM:614157]. NDNC10 is a nail disorder characterized by a variable degree of onychauxis (thick nails), hyponychia, and onycholysis of all nails, with claw-shaped fingernails in some individuals. No other anomalies of ectodermal tissues, including hair, teeth, sweat glands, or skin, are noted, and individuals with dysplastic nails have normal hearing and normal psychomotor development.
Note=Rare non-synonymous variants in FZD6 may contribute to neural tube defects, congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy.

Similarity:
Belongs to the G-protein coupled receptor Fz/Smo family.
Contains 1 FZ (frizzled) domain.

Database links:
UniProtKB/Swiss-Prot: O60353.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 日韩久草视频 | 精品国产AⅤ一区二区三区V免费 | 亚洲精品无码久久久久秋霞 | 国产乱AⅤ一区二区三区 | 国产色片免费色网视频 | 两女女百合互慰AV赤裸无遮挡 | 无码AV免费一区二区三区四区 | 久久热这里只有精品在线观看 | 九九热线视频只有这里最精品 | 俄罗斯ZOOM与人性ZOOM | 白丝美女被操黄色视频国产免费 | 欧美交换配乱吟粗大 | 欧美精品二区中文乱码字幕高清 | 在线三级网址 | 麻豆安全免费网址入口 | 香蕉久久夜色精品国产更新时间 | 浴室洗澡偷拍一区二区 | 青青草免费在线播放 | 91夜夜蜜桃臀一区二区三区 | 在线黄色观看 | 国产亚洲精品久久久久久青梅 | 男女作爱在线播放免费网站 | avtt亚洲| 国产精品毛片av999999 | 日韩一级淫片 | 2020久久超碰国产精品最新 | 91性视频 | 亚洲中文字幕无码久久 | 99热婷婷| 亚洲人午夜精品免费 | 永久黄软件免费观看 | 学生在线精品一区二区 | 国产性xxxx18免费观看视频 | 成人免费毛片内射美女-百度 | 日韩国产在线播放 | 欧美日韩视频免费观看 | 人人妻人人澡人人爽精品日 | 一级免费看片 | 日本成本人片免费网站 | 97在线观看免费版高清 | 精品中文一区 |