97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
亚洲激情三区,av手机天堂,日批免费观看视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Sumo 2+3/PE-Cy5.5 Conjugated antibody (bs-7338R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7338R-PE-Cy5.5
英文名稱 Rabbit Anti-Sumo 2+3/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的泛素樣蛋白Sumo2/3抗體
別    名 HSMT3; MGC117191; OTTHUMP00000115275; OTTHUMP00000115276; OTTHUMP00000115277; Sentrin 2; Small ubiquitin like modifier 2; Small ubiquitin like modifier protein 3; Small ubiquitin related modifier 2; Small ubiquitin related modifier 3; SMT3 A; SMT3 B; SMT3 H1; SMT3 H2; SMT3 homolog 1; SMT3 homolog 2; SMT3 homolog; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 2; SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 3; SMT3A; SMT3B; SMT3H1; SMT3H2; Sumo 2; Sumo 3; Sumo2; Sumo3; Suppressor of mif two 3 homolog 2; Suppressor of mif two 3 homolog 3; Ubiquitin like protein SMT3A; Ubiquitin like protein SMT3B; SUMO2_HUMAN; SUMO3_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  細胞周期蛋白  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Zebrafish, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 10.9+10.5kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Sumo 2+3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease.

Function:
SUMO proteins, such as Sumo 2 and Sumo 3, post-translationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. Sumo 2 and Sumo 3 are highly homologous, hence it is very difficult to produce antibodies which distinguish them.

Subunit:
Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains).

Subcellular Location:
Cytoplasmic (SUMO3) and Nuclear (SUMO2)

Tissue Specificity:
Broadly expressed.

Post-translational modifications:
Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.
Cleavage of precursor form by SENP1 or SENP2 is necessary for function.

Similarity:
Belongs to the ubiquitin family. SUMO subfamily.
Contains 1 ubiquitin-like domain.

Database links:

Entrez Gene: 6612 Human

Entrez Gene: 6613 Human

Entrez Gene: 170930 Mouse

Entrez Gene: 20610 Mouse

Entrez Gene: 397044 Pig

Entrez Gene: 499417 Rat

Entrez Gene: 690244 Rat

Omim: 602231 Human

Omim: 603042 Human

SwissProt: P61955 Cow

SwissProt: P55854 Human

SwissProt: P61956 Human

SwissProt: P61957 Mouse

SwissProt: Q9Z172 Mouse

SwissProt: P61958 Pig

SwissProt: P61959 Rat

SwissProt: Q5XIF4 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 成人免费看98影视mp4 | 夜夜草专业av导航 | 欧美一区黄色 | 欧美视频免费看 | 无码在线观看一区二区 | 午夜高清国产拍精品 | 欲求不满的寂寞人妻中文字幕 | 国产精品毛片va一区二区三区 | 欧美日韩国产综合视频 | 久9视频这里只有精品 | 色一情一乱一乱一区99av白浆 | 18禁止导深夜福利备好纸巾 | 日韩一本之道一区中文字幕 | 亚洲高清揄拍自拍AV | 五月花成人网 | 国产在线综合视频 | 亚洲综合无码久久精品综合 | 最好看的中文视频最好的中文 | 一级淫片aaa| 在线观看国产免费视频 | 亚洲精品亚洲人成人网 | 91精品国产自产在线观看自播 | 成人日韩精品 | 久久久久久一区 | 中文字幕在线观看不卡视频 | 性一交一乱一做一爰 | 天天躁日日躁狠狠躁2021a1 | 无码国产精品一区二区免费16 | 亚洲AV永久无码天堂网国产 | 亚洲AV综合色区无码二区偷拍 | 久久久久久久久艹 | ts国产人妖视频在线观看 | 国产www亚洲а∨天堂 | 日韩福利二区 | 一区国产精品 | 性深夜免费福利视频 | 一区二区在线播放视频 | 男人放进女人阳道动态图 | 国外xxx另类视频 | 国产清纯91天堂在线观看 | 日韩激情无码一级毛片 |