| 產(chǎn)品編號(hào) | bs-15563R-BF488 |
| 英文名稱 | Rabbit Anti-IFT46/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的細(xì)胞纖毛內(nèi)轉(zhuǎn)運(yùn)同源蛋白46抗體 |
| 別 名 | C11orf2; C11orf60; IFT46; IFT46_HUMAN; Intraflagellar transport protein 46 homolog. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞骨架 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IFT46 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: IFT46 is a 304 amino acid protein that belongs to the IFT46 family. IFT46 localizes to the cilium basal body but can also be found along the length of the cilium and is a part of a complex involved in intraflagellar transport (IFT). In addition, IFT46 is involved in the bi-directional movement of particles that is required for the assembly, maintenance, and functionality of primary cilia. Furthermore, IFT46 may be involved in skeletogenesis and chondrocyte maturation. Two isoforms exist due to alternate splicing events and the gene encoding IFT46 maps to human chromosome 11. Chromosome 11 houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11. Function: Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). Subunit: Part of the IFT complex B. Interacts with IFT57, IFT88 and DAW1 (By similarity). Subcellular Location: Cytoplasm, cytoskeleton, cilium basal body (By similarity). Cell projection, cilium (By similarity). Note=Expression is concentrated at the cilium basal body but is also detected along the length of the cilium (By similarity). Similarity: Belongs to the IFT46 family. Database links: Entrez Gene: 56912 Human SwissProt: Q9NQC8 Human Unigene: 533738 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
