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Rabbit Anti-NUDCD3/BF350 Conjugated antibody (bs-13766R-BF350)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-13766R-BF350
英文名稱 Rabbit Anti-NUDCD3/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的NUDCD3蛋白抗體
別    名 KIAA1068; NudC domain containing 3; NudC domain containing protein 3; NudC like protein; NUDCD 3; NudCL; OTTHUMP00000159457; NUDC3_HUMAN; NudC domain-containing protein 3. .  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Pig, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NUDCD3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Nuclear migration is essential for growth, development and cellular function of multicellular organisms. NUDCD3 (NudC domain containing 3) is a 361 amino acid protein that contains one CS domain and is phosphorylated upon DNA damage by either ATR or ATM. Ubiquitously expressed, NUDCD3 has been observed to colocalize with Golgi marker proteins during interphase of mitosis in HeLa cells, and is found at low levels in brain, ovary and heart. The gene encoding NUDCD3 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.

Function:
NUDCD3 functions to maintain the stability of dynein intermediate chain. Depletion of NUDCD3 results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. NUDCD3 levels increase after the G1/S transition.

Similarity:
Contains 1 CS domain.

Database links:

Entrez Gene: 23386 Human

Omim: 610296 Human

SwissProt: Q8IVD9 Human

Unigene: 488171 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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