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CD45 (bsm-30095M-mFV540)  
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產品編號 bsm-30095M-mFV540
英文名稱 CD45
中文名稱 mFV540標記的小鼠抗人CD45單克隆抗體
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 HI30
交叉反應 Human
產品應用 Flow-Cyt=10ul/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細胞定位 細胞膜 
免 疫 原 Recombinant human CD45 
亞    型 Mouse IgG1, k
純化方法 affinity purified by Protein G
緩 沖 液 0.01M PBS (pH7.4), 0.5% BSA, 0.02% Proclin300.
保存條件 Store at 2-8℃. Protect from light. Avoid freezing.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling

Function:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.

Subunit:
Binds GANAB and PRKCSH. Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Contains 2 tyrosine-protein phosphatase domains.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.

Post-translational modifications:
Heavily N- and O-glycosylated.

DISEASE:
Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains.

Database links:

Entrez Gene : 5788 Human

Entrez Gene : 19264 Mouse

Entrez Gene : 24699 Rat

Omim : 151460 Human

SwissProt : P08575 Human

SwissProt : P06800 Mouse

SwissProt : P04157 Rat

Unigene : 654514 Human

Unigene : 391573 Mouse

Unigene : 90166 Rat



CD45在活化信號轉導中起到調節作用,在確定CD45為一種PTPase之前就已證實了CD45參于細胞的活化和生長調節。
抗CD45抗體可以抑制PHA或CD3交聯所介導的T細胞增殖,還可抑制NK或細胞毒性T細胞對靶細胞的殺傷,抑制經CD2、CD3以及CD8膜分子介導的信號轉導作用。
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