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Rabbit Anti-EFHD2/FITC Conjugated antibody (bs-14520R-FITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-14520R-FITC
英文名稱 Rabbit Anti-EFHD2/FITC Conjugated antibody
中文名稱 FITC標記的EFHD2蛋白抗體
別    名 EF hand domain containing protein 2; EF hand domain family, member D2; EF-hand domain-containing protein D2; EFHD 2; EFHD2; EFHD2_HUMAN; RP3-467K16.3; Swiprosin 1; Swiprosin-1; SWS1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  神經生物學  信號轉導  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, Pig, Cow, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EFHD2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
EFHD2 is a 240 amino acid protein that regulates spontaneous apoptosis through the regulation of Bcl-xS abundance. Localized to membrane raft, Swiprosin-1 is expressed in lymphocytes and contains two EF-hand domains. The gene encoding Swiprosin-1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.

Function:
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.

Subcellular Location:
Membrane raft. In immature B-cell line WEHI231.

Tissue Specificity:
Found in lymphocytes; preferentially expressed in CD8+ cells.

Similarity:
Contains 2 EF-hand domains.

Database links:

Entrez Gene: 79180 Human

Entrez Gene: 27984 Mouse

Entrez Gene: 298609 Rat

SwissProt: Q96C19 Human

SwissProt: Q9D8Y0 Mouse

SwissProt: Q4FZY0 Rat

Unigene: 465374 Human

Unigene: 395598 Mouse

Unigene: 92713 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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