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Rabbit Anti-phospho-STK25 (Thr174)/PE Conjugated antibody (bs-10683R-PE)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-10683R-PE
英文名稱 Rabbit Anti-phospho-STK25 (Thr174)/PE Conjugated antibody
中文名稱 PE標記的絲氨酸/蘇氨酸激酶25抗體
別    名 STK25 (phospho T174); p-STK25 (phospho T174); Serine/threonine kinase 25; Serine/threonine kinase 25 (STE20 homolog, yeast); Serine/threonine kinase 25 (STE20 homolog, yeast), isoform CRA_a; Serine/threonine kinase 25 (yeast); Serine/threonine protein kinase 25; Serine/threonine-protein kinase 25; SOK-1; SOK1; Ste20 like kinase; Ste20 yeast homolog; Ste20-like; STE20-like kinase; Ste20/oxidant stress response kinase 1; Sterile 20 (oxidant stress response kinase 1); Sterile 20/oxidant stress-response kinase 1; STK25; STK25_HUMAN; Yeast Sps1/Ste20 related kinase 1; YSK1; C86992.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 細胞生物  神經生物學  信號轉導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Cow, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human STK25 around the phosphorylation site of Thr174
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.
Several mammalian kinases have been identified which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase STE20. STE20 is involved in relaying signals from G-protein coupled receptors, and it lies upstream of a MAP kinase kinase kinase. Mammalian STE20-like kinases include YSK1, KHS, GLK, NIK, HPK1, Krs-1, Krs-2 and GC kinase. YSK1 (yeast SPS/STE20-related kinase 1) is expressed in a wide variety of cell types and tissues and has been shown to have kinase activity. Unlike many of the other STE20-like kinases, however, overexpression of YSK1 does not lead to activation of the SAPK/JNK pathway.

Function:
Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.

Subunit:
Homodimer.

Subcellular Location:
Cytoplasm. Golgi apparatus. Localizes to the Golgi apparatus.

Tissue Specificity:
Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 10494 Human

Entrez Gene: 51765 Human

Entrez Gene: 8428 Human

Omim: 300547 Human

Omim: 602255 Human

Omim: 604984 Human

SwissProt: O00506 Human

SwissProt: Q9P289 Human

SwissProt: Q9Y6E0 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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