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Rabbit Anti-CDKN2B/Biotin Conjugated antibody (bs-20246R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-20246R-Bio
英文名稱 Rabbit Anti-CDKN2B/Biotin Conjugated antibody
中文名稱 生物素標記的細胞周期蛋白依賴性激酶抑制劑2B抗體
別    名 CDK inhibitory protein; CDK4B Inhibitor; CDKN2B; Cyclin dependent kinase 4 inhibitor B; Cyclin Dependent Kinase Inhibitor 2B; Cyclin dependent kinase inhibitor 2B p15 inhibits CDK4; Cyclin-dependent kinases 4 and 6 binding protein; INK4B; MTS 2; MTS2; Multiple Tumor Supressor 2; p14 CDK inhibitor; p14 INK4b; P15; p15 CDK inhibitor; p15 inhibits CDK4; p15 INK4b; P15(INK4B); p15INK4B; TP 15; TP15.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  細胞生物  免疫學  信號轉導  干細胞  細胞周期蛋白  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CDKN2B
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
p15 INK4b / MTS 2 (Mitotic Inhibitor / Suppressor Protein) is a specific inhibitor of cdk 4 / cdk 6 and is periodically expressed during the cell cycle. Reportedly, p15 INK4b expression is induced approximately 30 fold in human keratinocytes by treatment with TGF beta, suggesting that p15 INK4b may act as an effector of TGF beta mediated cell cycle arrest. p15 INK4b is mapped to chromosome 9p21, a region of frequent loss in a wide variety of cancers.

Function:
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.

Subunit:
Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6.

Subcellular Location:
Cytoplasm. Note=Also found in the nucleus.

Tissue Specificity:
Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.

Similarity:
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Contains 4 ANK repeats.

Database links:

Entrez Gene: 1030 Human

Entrez Gene: 12579 Mouse

Entrez Gene: 25164 Rat

Omim: 600431 Human

SwissProt: P42772 Human

SwissProt: P55271 Mouse

SwissProt: P55272 Rat

Unigene: 72901 Human

Unigene: 423094 Mouse

Unigene: 105626 Rat

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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