97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日韩激情在线观看,91网站国产,国产视一区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-MUC12/APC Conjugated antibody (bs-17903R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-17903R-APC
英文名稱 Rabbit Anti-MUC12/APC Conjugated antibody
中文名稱 APC標記的粘蛋白12抗體
別    名 MUC11; MUC12; Mucin 12; Mucin-12; MUC12_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  信號轉導  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 556kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MUC12
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Membrane-associated and secretory mucins are high molecular weight glycoproteins of the glycocalyx (polysaccharide biofilm) that protects mucosal epithelium from particulate matter and microorganisms. The mucin family consists of Mucins 1-4, Mucin 5 (AC and B), Mucins 6-8, Mucins 11-13 and Mucins 15-17. A family of four related Mucin genes (MUC2, MUC5AC, MUC5B and MUC6) encode the major secreted mucins. Mucin 12 contains a predicted transmembrane domain; two extracellular cysteine-rich EGF-like domains; a coiled-coil region; and a domain consisting of serine-, threonine-, and proline-rich degenerate tandem repeats of 28 amino acids, a structural feature typical of mucins. Mucin 12 transcript (>12 kb) is present in colon, pancreas, prostate and uterus. Colorectal tumors can have low Mucin 12 transcript levels in comparison to normal colon tissues.

Function:
Human MUC12 (Mucin 12) is a novel mucin of epithelial mucins, which are large, secreted or cell surface glycoproteins involved in epithelial cell protection, adhesion modulation, and signaling. Using differential display on RNA from paired normal colonic mucosa and primary colorectal tumor, MUC12 is identified as one of the 2 partial cDNAs representing novel mucin genes as well as MUC11. They are downregulated in colorectal tumors.The deduced MUC12 protein contains a predicted transmembrane domain, 2 extracellular cysteine-rich EGF-like domains, a coiled-coil region, and a domain consisting of serine-, threonine-, and proline-rich degenerate tandem repeats of 28 amino acids, a structural feature typical of mucins. Human MUC12 shares high sequence homology with MUC3 and MUC4 . Northern blot analysis of 50 different normal tissues detected MUC12 expression in colon, pancreas, prostate, and uterus, with highest expression in colon. The MUC12 transcript is large, estimated to be longer than 12 kb. Expression of MUC12 was downregulated or absent in 6 of 15 (40%) colorectal tumors, as compared with matched normal colonic tissues. MUC12 expression was not detected in any of 6 colorectal cancer cell lines examined.

Subcellular Location:
Cell Membrane

Tissue Specificity:
Ubiquitous, with higher expression in colon. Down-regulated in colorectal cancer as well as in the colon of patients with ulcerative colitis (UC) and Crohn's disease (CD).

Similarity:
Contains 1 EGF-like domain.
Contains 1 SEA domain.

Database links:

Entrez Gene: 10071 Human

Omim: 604609 Human

SwissProt: Q9UKN1 Human

Unigene: 489355 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 精品人妻少妇一区二区三区 | 国产永久视频 | 中文字幕一区二区日韩精品绯色 | 亚洲爆乳少妇无码激情 | 精品人妻无码专区在中文字幕 | 久久久久人妻精品区一三寸 | 欧美一级大黄大黄大色毛片小说 | 四虎成人免费在线 | 说英雄谁是英雄免费观看 | 色爱av综合网站 | 91少妇香蕉久久精 | 色八a级在线观看 | 亚洲日韩中文在线精品第一 | 国产国语在线播放视频 | 四虎地址 | 无码动漫性爽xo视频在线 | 在线A亚洲老鸭窝天堂 | 91视频www. | 久久久久久一区国产精品 | 国产精品5c5c5c | 久久久亚洲精品中文字幕 | 中文字幕国产视频 | av九九| 午夜久操 | 成人国产一区二区三区精品麻豆 | 亚洲AV无码专区亚洲AV网站 | 性欧美18一19sex性欧美 | 日韩欧美中文免费 | 国产一区二区在线在线 | 4399午夜理伦免费播放大全 | 国产99久久久久久 | 免费视频一二三 | 在线观看国产成人av片 | 二次元人物桶二次元人物免费 | 一区二区视频免费在线观看 | 善良的表妹hd高清中文 | 久久特级av一级毛片 | 欧美精品一区二区三区四区 | 免费av不卡在线观看 | 日韩精品欧美在线成人 | 亚洲啪啪av无码片 |