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Rabbit Anti-ZDHHC2/ZNF372/APC Conjugated antibody (bs-18480R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-18480R-APC
英文名稱 Rabbit Anti-ZDHHC2/ZNF372/APC Conjugated antibody
中文名稱 APC標記的鋅指蛋白372抗體
別    名 DHHC-2; Palmitoyltransferase ZDHHC2; Ream; Rec; Reduced expression associated with metastasis protein; Reduced expression in cancer protein; ZDHC2_HUMAN; Zdhhc2; Zinc finger DHHC domain-containing protein 2; Zinc finger protein 372; ZNF372.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  鋅指蛋白  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Horse, Rabbit, Monkey, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZDHHC2/ZNF372
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
ZDHHC2 is a 367 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger. The ubiquitously expressed ZDHHC2 protein functions as a palmitoyltransferase that uses palmitoyl-CoA and catalyzes the conversion of target proteins, namely GAP-43 and PSD-95, to S-palmitoyl proteins. Defects in the gene encoding ZDHHC2 are found in colorectal cancer and hepatocellular carcinoma, suggesting a role for ZDHHC2 in tumorigenesis. The gene encoding human ZDHHC2 maps to chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

Function:
Palmitoyltransferase specific for GAP43 and DLG4/PSD95.

Subcellular Location:
Membrane.

Tissue Specificity:
Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis.

DISEASE:
Note=Mutations in ZDHHC2 are found in hepatocellular carcinoma and colorectal cancer.

Similarity:
Belongs to the DHHC palmitoyltransferase family.
Contains 1 DHHC-type zinc finger.

Database links:

Entrez Gene: 51201 Human

Entrez Gene: 70546 Mouse

Entrez Gene: 246326 Rat

SwissProt: Q9UIJ5 Human

SwissProt: P59267 Mouse

Unigene: 726197 Human

Unigene: 34326 Mouse

Unigene: 17310 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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