97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
亚洲欧美一区二区三,黄色网址视频免费,欧美日韩在线国产
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-MICALL2/JRAB/PE-Cy5 Conjugated antibody (bs-18936R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-18936R-PE-Cy5
英文名稱 Rabbit Anti-MICALL2/JRAB/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的MICAL樣蛋白2抗體
別    名 FLJ23471; FLJ41996; FLJ44858; FLJ45410; JRAB; Junctional Rab13 binding protein; MGC46023; MICAL L2; MICAL like 2; MICAL like protein 2; MICALL2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經(jīng)生物學  轉錄調節(jié)因子  鋅指蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MICALL2/JRAB
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
JRAB is a 904 amino acid protein with one CH (calponin-homology) domain and one LIM zinc-binding domain. JRAB has been shown to interact with Rab13 and Rab8 to facilitate cellular transport of claudin-1, occludin, and E-cadherin. This interaction is vital for the coordination of the assembly of tight junctions (TJs) and adherens junctions (AJs). Dynamic turnover (endocytic recycling) of cell-to-cell AJs and TJs is essential for epithelial morphogenesis during normal development and differentiation. The endocytic recycling of occludin and cluadin proteins is part of an ongoing process of restructuring and maintaining cell junctions, especially at TJs. JRAb and Rab13 have also been implicated in the carcinoma metastasis event of epithelial cell scattering. This event shows Rab13 and JRAB colocalizing with F-Actin in lamellipodial structures prior to cell scattering.

Function:
Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth.

Subunit:
Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly. Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling By similarity. Interacts with RAB8B By similarity. Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation By similarity. Interacts (via CH domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain).

Subcellular Location:
Cell membrane; Cytoplasmic; cytoskeleton

Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 1 LIM zinc-binding domain.

Database links:

Entrez Gene: 79778 Human

SwissProt: Q8IY33 Human

Unigene: 376617 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 日本aⅴ日本高清视频影片www | 人妻AⅤ无码专区 | 亚洲国产欧美在线人成最新 | 日本在线看片免费人成视频 | 日本高清不卡中文字幕免费 | 黄网站在线观 | 尤物网址在线观看 | 国产字幕制服中文在线 | 99久久夜色精品国产亚洲av卜 | 91蜜桃视频在线观看 | 成人h动漫无码网站久久 | 亚洲情XO亚洲色XO无码 | 欧美成人看片 | 午夜影院免费观看 | 久久伊人天堂 | 欧美黑人巨大xxxxxx | 天堂网在线WWW最新版资源 | 国产精品一区一区三区 | 亚洲精品99999 | 好久不见在线观看免费高清 | 午夜片在线 | 亚洲xxxx天美| 天天搞美女视频 | 狠狠色狠狠色综合 | 国产精品毛片一区二区 | 久久a级毛片免费观看 | 外企女老板被洋老外啪啪 | 麻豆一区二区大豆行情 | 亚洲熟女少妇一区二区 | 草草亚洲视频 | 国产成人综合激情视频在线观看 | 久精品久久 | 色视频网站在线观看 | av线网| JAPANESE人妻中文字幕 | 亚洲最新无码中文字幕久久 | 国产特黄一级免费AA大片 | 99久久精品免费观看国产 | 久久久综合久久 | 看免费的毛片 | 亚洲色图狠狠爱 |