97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
黄视频免费观看网站,国产被窝福利一区二区,国产欧美性成人精品午夜
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-MICALL2/JRAB/PE-Cy5.5 Conjugated antibody (bs-18936R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-18936R-PE-Cy5.5
英文名稱 Rabbit Anti-MICALL2/JRAB/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的MICAL樣蛋白2抗體
別    名 FLJ23471; FLJ41996; FLJ44858; FLJ45410; JRAB; Junctional Rab13 binding protein; MGC46023; MICAL L2; MICAL like 2; MICAL like protein 2; MICALL2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  轉錄調節因子  鋅指蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MICALL2/JRAB
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
JRAB is a 904 amino acid protein with one CH (calponin-homology) domain and one LIM zinc-binding domain. JRAB has been shown to interact with Rab13 and Rab8 to facilitate cellular transport of claudin-1, occludin, and E-cadherin. This interaction is vital for the coordination of the assembly of tight junctions (TJs) and adherens junctions (AJs). Dynamic turnover (endocytic recycling) of cell-to-cell AJs and TJs is essential for epithelial morphogenesis during normal development and differentiation. The endocytic recycling of occludin and cluadin proteins is part of an ongoing process of restructuring and maintaining cell junctions, especially at TJs. JRAb and Rab13 have also been implicated in the carcinoma metastasis event of epithelial cell scattering. This event shows Rab13 and JRAB colocalizing with F-Actin in lamellipodial structures prior to cell scattering.

Function:
Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth.

Subunit:
Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly. Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling By similarity. Interacts with RAB8B By similarity. Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation By similarity. Interacts (via CH domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain).

Subcellular Location:
Cell membrane; Cytoplasmic; cytoskeleton

Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 1 LIM zinc-binding domain.

Database links:

Entrez Gene: 79778 Human

SwissProt: Q8IY33 Human

Unigene: 376617 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲永久精品ww.7491进入 | 精品欧美一区二区精品久久 | 精品国产乱码久久久久久密桃99 | 亚洲精品亚洲人成人网 | avtt天堂资源网站 | 欧美最猛黑人xxxx黑人表情 | JAPAN黑人极大黑炮 | 亚洲国产婷婷香蕉久久久久久99 | 亚洲欧美日韩综合在线丁香 | 国产精品国产片 | 国产播放啪视频免费视频 | 色国产精品一区在线观看 | 国产AV无码精品国产精品 | 被公侵犯的漂亮人妻 | 电锯惊魂1在线观看 | 久久99精品久久久 | av久色| 一性一交一伦一色一情人 | 91肥熟| 亚洲AV成人片色在线观看蜜桃 | 国产视频手机在线观看 | 亚洲精品久久久一区二区图片 | 国产成人久久婷婷精品流白浆 | 国产精品无码专区网站 | 国产二级一片内射视频播放 | 国产AV永久无码精品网站 | 丰满妇女做a级毛片免费观看 | 御姐av在线| 狠狠艹夜夜艹 | 欧美阿v视频 | 国产精品婷婷不卡久久久 | 精品欧美不卡一区二区在线观看 | 日韩人妻无码AV一区二区三区 | 精品少妇一区二区三区在线播放 | 深夜福利成人 | 欧美日韩一区免费 | 九九九国产视频 | 日本亚洲不卡视频 | 色视频在线观看免费视频 | 亚洲a一区二区三区 | 国产精品福利自产拍在线观看 |