97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
免费AV网站,成人a毛片久久免费播放,九九热在线观看免费视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-MICALL2/JRAB/BF594 Conjugated antibody (bs-18936R-BF594)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-18936R-BF594
英文名稱 Rabbit Anti-MICALL2/JRAB/BF594 Conjugated antibody
中文名稱 BF594標記的MICAL樣蛋白2抗體
別    名 FLJ23471; FLJ41996; FLJ44858; FLJ45410; JRAB; Junctional Rab13 binding protein; MGC46023; MICAL L2; MICAL like 2; MICAL like protein 2; MICALL2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  轉錄調節因子  鋅指蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MICALL2/JRAB
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
JRAB is a 904 amino acid protein with one CH (calponin-homology) domain and one LIM zinc-binding domain. JRAB has been shown to interact with Rab13 and Rab8 to facilitate cellular transport of claudin-1, occludin, and E-cadherin. This interaction is vital for the coordination of the assembly of tight junctions (TJs) and adherens junctions (AJs). Dynamic turnover (endocytic recycling) of cell-to-cell AJs and TJs is essential for epithelial morphogenesis during normal development and differentiation. The endocytic recycling of occludin and cluadin proteins is part of an ongoing process of restructuring and maintaining cell junctions, especially at TJs. JRAb and Rab13 have also been implicated in the carcinoma metastasis event of epithelial cell scattering. This event shows Rab13 and JRAB colocalizing with F-Actin in lamellipodial structures prior to cell scattering.

Function:
Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth.

Subunit:
Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly. Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling By similarity. Interacts with RAB8B By similarity. Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation By similarity. Interacts (via CH domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain).

Subcellular Location:
Cell membrane; Cytoplasmic; cytoskeleton

Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 1 LIM zinc-binding domain.

Database links:

Entrez Gene: 79778 Human

SwissProt: Q8IY33 Human

Unigene: 376617 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 一区二区三区高清在线视频 | 斗罗大陆3龙王传说第四季免费观看 | 国产精品中文字幕在线观看 | 亚洲精品熟女国产 | www中文字幕 | 日韩爱爱小视频 | 精品国产www | 美丽姑娘免费高清观看 | 国产精品自产拍在线观看55 | 中国黄色网址 | 丁香五月欧美成人 | 亚洲二区三区在线 | 伊人久久精品欧洲综合网 | 午夜一级 | 狂野欧美性猛交bbbb | 亚洲高清视频一区二区 | 高中男生自慰网站xnxx免费 | 久热精品在线观看 | 欧美亚洲中日韩中文字幕在线 | 最新亚洲人成无码WWW | 国产免费国产 | 女人18毛片a级毛片免费视频 | 欧美日韩成人在线视频 | 人妻熟女av | 黄色美女一级片 | 国产精亚洲视频 | 精品一区二区三区四区蜜桃 | 91视频在线观看网 | 国内精品国产三级国产 | 久久久6精品成人午夜51777 | 小尤奈无码视频 | 伊人福利| 日日日日日日bbbbb视频 | xxxx另类黑人 | 欧美黑人狂躁日本寡妇 | 各种场合大胆露出在线看 | 欧美日韩国产色综合视频 | 国产黄大片在线观看画质优化 | 亚洲AV网址在线 | 一区av在线 | 一级二级三级毛片 |