97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
天天摸天天做天天爽天天弄,青青草视频播放器,性国产se╳o色欲a片欢迎观看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-TUBB3 (Ser172)/RBITC Conjugated antibody (bs-20288R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-20288R-RBITC
英文名稱 Rabbit Anti-phospho-TUBB3 (Ser172)/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的磷酸化神經細胞特異性微管蛋白抗體
別    名 beta III Tubulin (phospho S172); p-beta III Tubulin (phospho S172); TUBB3(phospho S172); beta 4; MC1R; TBB3_HUMAN; TUBB 3; TUBB 4; TUBB3; TUBB4; Tubulin beta 3 chain; Tubulin beta 4; Tubulin beta III; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin beta-III.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 細胞生物  免疫學  神經生物學  信號轉導  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Rabbit, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50-55kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human TUBB3 around the phosphorylation site of Ser172
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Tubulin is a major cytoskeleton component that has five distinct forms, designated a, b, g, d and e tubulin. a and b tubulins form heterodimers which multimerize to form a microtubule filament. Multiple b Tubulin isoforms (b1, b2, b3, b4, b5, b6 and b8) have been characterized and are expressed in mammalian tissues. b1 and b4 are present throughout the cytosol, b2 is present in the nuclei and nucleoplasm, and b3 is a neuron-specific cytoskeletal protein. g Tubulin forms the gammasome, which is required for nucleating microtubule filaments at the centrosome. Both d Tubulin and e Tubulin are associated with the centrosome. d Tubulin is a homolog of the Chlamydomonas d Tubulin Uni3 and is found in association with the centrioles, whereas e Tubulin localizes to the pericentriolar material. e Tubulin exhibits a cell cycle-specific pattern of localization; first associating with only the older of the centrosomes in a newly duplicated pair, and later associating with both centrosomes.

Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance.

Subunit:
Dimer of alpha and beta chains.

Subcellular Location:
Cytoplasm; cytoskeleton.

Tissue Specificity:
Expression is primarily restricted to central and peripheral nervous system.

Post-translational modifications:
Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.

DISEASE:
Defects in TUBB3 are the cause of congenital fibrosis of extraocular muscles type 3A (CFEOM3A) [MIM:600638]. A congenital ocular motility disorder marked by restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. It is clinically characterized by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. Congenital fibrosis of extraocular muscles type 3 presents as a non-progressive, autosomal dominant disorder with variable expression. Patients may be bilaterally or unilaterally affected, and their oculo-motility defects range from complete ophthalmoplegia (with the eyes fixed in a hypo- and exotropic position), to mild asymptomatic restrictions of ocular movement. Ptosis, refractive error, amblyopia, and compensatory head positions are associated with the more severe forms of the disorder. In some cases the ocular phenotype is accompanied by additional features including developmental delay, corpus callosum agenesis, basal ganglia dysmorphism, facial weakness, polyneuropathy.

Similarity:
Belongs to the tubulin family.

Database links:

Entrez Gene: 10381 Human

Entrez Gene: 22152 Mouse

Entrez Gene: 246118 Rat

Omim: 602661 Human

SwissProt: Q13509 Human

SwissProt: Q9ERD7 Mouse

SwissProt: Q4QRB4 Rat

Unigene: 511743 Human

Unigene: 40068 Mouse

Unigene: 43958 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 精品国产视频在线 | 亚洲精品无码永久在线观看性色 | 一级全黄男女免费大片 | 秋霞理论福利院 | 91精品国产9 | 中日韩一区二区 | 视频一区视频二区视频 | a级国产乱理伦片在线观看 www在线免费 | aV无码久久久久不卡蜜桃 | 国产成网站18禁止久久影院 | 小尤奈无码视频 | 国产黑色丝袜在线观看下 | 五月天狠狠色 | 97久久国产 | 日日噜噜大屁股熟妇 | 人人爽人人爽人人爽人人片av | 精产国产伦理一二三区 | 日韩熟女精品一区二区三区 | 天天做天天爱天天综合网2021 | 欧美日韩国产精品综合 | 成人免费毛片内射美女-百度 | 无套内射chinesehd熟女 | 亚洲日韩欧美内射教官 | 国产一区二区四区在线观看 | 国产三级欧美三级 | 五月天婷婷影视 | 亚洲福利av | 91超碰人人做人人爽 | 久久日韩国产精品免费 | 51国产偷自视频区视频免费的 | 伦理片一区二区三区 | 亚洲欧美在线成人 | 91毛片视频 | 亚洲欧洲日产国码韩国 | 最新av免费在线 | 国产精品久久久久9999 | 伊人久久精品欧洲综合网 | 激情久久久久久久 | 91叼嘿| 午夜剧场成年 | 日韩免费视频播放 |