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Rabbit Anti-KCNT1/Gold Conjugated antibody (bs-20327R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-20327R-Gold
英文名稱 Rabbit Anti-KCNT1/Gold Conjugated antibody
中文名稱 膠體金標記的鉀離子通道亞家族T成員1抗體
別    名 bA100C15.2; EIEE14; ENFL5; KCa4.1; KCNT1; KCNT1_HUMAN; Potassium channel subfamily T member 1; Potassium channel, subfamily T, member 1; SLACK.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  神經生物學  通道蛋白  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, 
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 137kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KCNT1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Function:
Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro).

Subcellular Location:
Cell membrane.

Tissue Specificity:
Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle.

Post-translational modifications:
Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity.

Similarity:
Belongs to the potassium channel family.
Calcium-activated (TC 1.A.1.3)
subfamily. KCa4.1/KCNT1 sub-subfamily.
Contains 1 RCK N-terminal domain.


Database links:

Entrez Gene: 57582 Human

Entrez Gene: 227632 Mouse

Entrez Gene: 60444 Rat

Omim: 608167 Human

SwissProt: Q5JUK3 Human

SwissProt: Q6ZPR4 Mouse

SwissProt: Q9Z258 Rat

Unigene: 104950 Human

Unigene: 119462 Mouse

Unigene: 162642 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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