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Rabbit Anti-SAA1/Serum Amyloid A/Gold Conjugated antibody (bs-19359R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-19359R-Gold
英文名稱 Rabbit Anti-SAA1/Serum Amyloid A/Gold Conjugated antibody
中文名稱 膠體金標記的血清淀粉樣蛋白A抗體
別    名 amyloid A, serum; Amyloid fibril protein AA; Amyloid protein A; MGC111216; PIG4; SAA; SAA2; Serum amyloid A protein; serum amyloid A-1 protein; serum amyloid A1; TP53I4; Tumor protein p53 inducible protein 4.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  細胞生物  免疫學  神經(jīng)生物學  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SAA1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]

Function:
Major acute phase reactant. Apolipoprotein of the HDL complex.

Subunit:
Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed by the liver; secreted in plasma (at protein level).

Post-translational modifications:
This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.

DISEASE:
Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
Elevated serum SAA1 protein levels may be associated with lung cancer.

Database links:

Entrez Gene: 6288 Human

Entrez Gene: 20208 Mouse

Omim: 104750 Human

SwissProt: P0DJI8 Human

SwissProt: P05366 Mouse

Unigene: 632144 Human

Unigene: 148800 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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