97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久久色资源站,麻豆安全免费网址入口,高清国产一区二区三区四区五区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-PABP2/Cy5.5 Conjugated antibody (bs-19994R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-19994R-Cy5.5
英文名稱 Rabbit Anti-PABP2/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的多聚腺苷酸結合蛋白2抗體
別    名 Nuclear poly(A) binding protein 1; PAB2; PABII; PABP2; PABPN1; Poly(A) binding protein 2; Polyadenylate binding nuclear protein 1; Polyadenylate binding protein 2; ROX2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  結合蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Dog, Cow, Horse, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PABP2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]

Function:
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).

Subunit:
May interact with SETX (PubMed:21700224). Monomer and homooligomer. Binds RNA as a monomer and oligomerizes when bound to poly(A). Interacts with PAPOLA, but only in presence of oligo(A) RNA. Interacts with transportin. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Association in a ternary complex with CPSF4 and influenza A virus NS1 blocks pre-mRNAs processing, thereby preventing nuclear export of host cell mRNAs. Associates in a single complex with SKIP and MYOD1 and interacts with SKIP in differentiated myocytes. Interacts with NUDT21/CPSF5.

Subcellular Location:
Cytoplasmic and Nuclear.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Arginine dimethylation is asymmetric and involves PRMT1 and PRMT3. It does not influence the RNA binding properties (By similarity).

DISEASE:
The disease is caused by mutations affecting the gene represented in this entry. Disease description:A form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.

Similarity:
Contains 1 RRM (RNA recognition motif) domain.

Database links:

Entrez Gene: 8106 Human

Entrez Gene: 18459 Mouse

Omim: 602279 Human

SwissProt: Q86U42 Human

SwissProt: Q8CCS6 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产精品高潮呻吟av久久动 | 久久综合香蕉国产蜜臀av | 国产一级黄色录像片 | 精品福利视频一区二区三区 | 欧美四虎影院 | 男人插女人逼逼视频 | www.久久| 精品一区二区三区日本视频 | 玩弄人妻奶水无码av在线 | 精品无码AV无码专区 | 精品成人免费 | 国产91精品一区二区三区四区 | xxxx18欧美 | 理论片一级片 | 91黄色免费看 | 亚洲色成人一区二区三区 | 91国偷自产一区二区三区蜜臀 | 亚洲乱码日产精品bd在线观看 | 中文精品一区二区三区四区 | 精品久久久一 | 国产女教师高潮叫床视频网站 | 久草在线资源总站 | av久久伊人精品中文字幕 | 成人性生交大片100部 | 久艹精品 | 日韩一级成人av | 久久999精品久久久有什么优势 | 亚洲黄色在线免费观看 | 人妻无码中文字幕永久有效视频 | 亚洲成年在线 | 99re视频在线免费观看 | 日韩AV无码社区一区二区三区 | 中文字幕v亚洲ⅴv天堂 | 992tv免费观看线路1 | 国产高清www午色夜 国产精品yjizz视频网 | 免费能直接在线观看黄的视频 | 日韩精品一区二区三区中文无码 | 国产夜色av | 人人妻人人澡人人爽超污 | 日本一级a毛片免费观看 | 久久久久亚洲AV无码网站 |