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Rabbit Anti-PREX2/PE-Cy5 Conjugated antibody (bs-19960R-PE-Cy5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-19960R-PE-Cy5
英文名稱 Rabbit Anti-PREX2/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的磷脂酰肌醇PREX2抗體
別    名 5)-dependent Rac exchanger 2; 5-trisphosphate-dependent Rac exchanger 2 protein; 6230420N16Rik; DEP domain-containing protein 2; DEP.2; DEPDC2; FLJ12987; P-Rex2; Phosphatidylinositol 3; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2; PREX2; PREX2_HUMAN; PtdIns(3; PtdIns(3,4,5)-dependent Rac exchanger 2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 183kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PREX2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 Function:
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.

Subunit:
Interacts with RAC1.

Tissue Specificity:
Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart.

Similarity:
Contains 2 DEP domains.
Contains 1 DH (DBL-homology) domain.
Contains 2 PDZ (DHR) domains.
Contains 1 PH domain.

Database links:

Entrez Gene: 80243 Human

Entrez Gene: 109294 Mouse

Entrez Gene: 312912 Rat

Omim: 612139 Human

SwissProt: Q70Z35 Human

SwissProt: Q3LAC4 Mouse

Unigene: 591867 Human

Unigene: 123247 Mouse

Unigene: 229579 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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