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Rabbit Anti-Endophilin II/Gold Conjugated antibody (bs-19747R-Gold)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-19747R-Gold
英文名稱 Rabbit Anti-Endophilin II/Gold Conjugated antibody
中文名稱 膠體金標記的胞吞蛋白Endophilin 2抗體
別    名 SH3 containing Grb 2 like 1 protein; Endophilin II; CNSA1; EEN; EEN fusion partner of MLL; Endophilin-2; Endophilin-A2; Extra 11 19 leukemia fusion gene; Extra eleven-nineteen leukemia fusion gene protein; Fusion partner of MLL; MGC111371; SH3 containing Grb 2 like 1 protein; SH3 containing protein EEN; SH3 domain GRB2 like 1; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; SH3D2B; SH3G1_HUMAN; SH3GL1; SH3P8.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  細胞生物  免疫學  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Endophilin II
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Function:
Implicated in endocytosis. May recruit other proteins to membranes with high curvature.

Subcellular Location:
Cytoplasm. Early endosome membrane. Associated with postsynaptic endosomes in hippocampal neurons.

Tissue Specificity:
Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.

DISEASE:
Note=In some cases of acute leukemia, a translocation results in the formation of a MLL-EEN fusion gene.

Similarity:
Belongs to the endophilin family.
Contains 1 BAR domain.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 512719 Cow

Entrez Gene: 6455 Human

Entrez Gene: 20405 Mouse

Entrez Gene: 81922 Rat

Omim: 601768 Human

SwissProt: Q2KJA1 Cow

SwissProt: Q99961 Human

SwissProt: Q62419 Mouse

SwissProt: O35964 Rat

Unigene: 97616 Human

Unigene: 1773 Mouse

Unigene: 8762 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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