97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日韩欧群交P片内射中文,久久影院精品,色呦呦久久
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Perforin/BF594 Conjugated antibody (bs-20270R-BF594)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-20270R-BF594
英文名稱 Rabbit Anti-Perforin/BF594 Conjugated antibody
中文名稱 BF594標記的穿孔素抗體
別    名 Cytolysin; FLH2; HPLH2; Lymphocyte pore forming protein; Lymphocyte pore-forming protein; MGC65093; P1; PERF_HUMAN; Perforin 1; Perforin 1 precursor; Perforin 1 preforming protein; Perforin-1; PFP; PGFL; PIGF; PIGF-2; PLGF; Pore forming protein; PRF 1; PRF1; SHGC-10760.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  淋巴細胞  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, 
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Perforin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].

Function:
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.

Subunit:
Monomer, as sobluble protein. Homooligomer. Oligomerization is required for pore formation.

Subcellular Location:
Cytoplasmic granule lumen. Secreted. Cell membrane. Endosome lumen. Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes.

Post-translational modifications:
N-glycosylated.

DISEASE:
Defects in PRF1 are the cause of hemophagocytic lymphohistiocytosis familial type 2 (FHL2) [MIM:603553]; also known as HPLH2. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T lymphocytes in lymph nodes, spleen, and other organs is also found.

Similarity:
Belongs to the complement C6/C7/C8/C9 family.
Contains 1 C2 domain.
Contains 1 EGF-like domain.
Contains 1 MACPF domain.

Database links:

Entrez Gene: 5551 Human

Entrez Gene: 18646 Mouse

Entrez Gene: 50669 Rat

Omim: 170280 Human

SwissProt: P14222 Human

SwissProt: P10820 Mouse

SwissProt: P35763 Rat

Unigene: 2200 Human

Unigene: 240313 Mouse

Unigene: 11206 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产精品蜜臀av免费观看四虎 | 日本视频一区二区 | 久久人人九九 | 色婷婷av一区二区三区软件 | 亚洲欧美日韩综合俺去了 | 日韩人妻无码AV一区二区三区 | 无码人妻精一区二区三区 | 成年人在线免费观看视频网站 | 宅男一区 | 在线观看国产成人av片 | 午夜剧场成年 | 色婷婷成人综合激情免费视频 | 亚洲理论av | 中文字幕一区二区三区av | 狼人无码中文在线观看 | 美日韩一级大片 | av中文字幕在线观看第一页 | 国产亚洲第一伦理片在线c 啪啪网址大全 | 国产自精品 | 日本大片在线观看 | 精品久久久久久无码人妻A片 | 亚洲第一黄色网址 | 女人被添全过程A片久久AV | 国产第一页福利影院 | 在线免费毛片视频 | 国产大BBWBBWHD视频 | 欧美激情网页 | 午夜AV无码福利免费看网站 | 国产v精品成人免费视频400条 | 男男GAY亚洲帅哥在线 | 亚洲自拍偷拍综合网 | 麻豆视频网页 | aaa级黄色大片 | 手机在线观看亚洲 | 精品无码国产污污污免费网站 | 麻豆人妻少妇精品无码专区 | 久9视频这里只有精品 | 欧美日本中文 | 小荡货奶真大水真多紧视频 | 国产9999精品 | 亚洲国产天堂久久综合网 |