97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产明星视频三级a三级点,亚洲福利视频在线,日本不卡1区2区3区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-JNK1 + JNK2 + JNK3 (T183 + T183 + T221)/Cy5 Conjugated antibody (bs-4163R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-4163R-Cy5
英文名稱 Rabbit Anti-phospho-JNK1 + JNK2 + JNK3 (T183 + T183 + T221)/Cy5 Conjugated antibody
中文名稱 Cy5標記的磷酸化氨基末端激酶1/2/3抗體
別    名 JNK1 + JNK2 + JNK3 (phospho T183 + T183 + T221); JNK1 (phospho T183); p-JNK1 (phospho T183); MAPK8 (phospho T183); JNK1 + JNK2 (phospho Thr183 + Thr183); JNK1 + 2 (phospho Thr183+Thr183); p-JNK; c Jun N terminal kinase 1; C-JUN kinase 1; EC 2.7.11.24; JAK 1A; JAK1A; JNK 1; JNK 46; JNK; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; MAPK8; Mitogen activated protein kinase 8; p54 gamma; PRKM 8; PRKM8; Protein kinase JNK1; Protein kinase, mitogen-activated, 8; SAPK 1; SAPK gamma; SAPK1; Stress activated protein kinase JNK1; Stress-activated protein kinase JNK1; Tyrosine protein kinase JAK1; AI849689; MK08_HUMAN; MK09_HUMAN; MK10_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  信號轉導  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human JNK1/JNK2/JNK3 around the phosphorylation site of T183/T183/T221
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]

Function:
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH.
JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Subcellular Location:
Cytoplasm. Nucleus.

Post-translational modifications:
Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by TAOK2.

Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 5599 Human

Entrez Gene: 5601 Human

Entrez Gene: 5602 Human

Entrez Gene: 26414 Mouse

Entrez Gene: 26419 Mouse

Entrez Gene: 26420 Mouse

Entrez Gene: 116554 Rat

Entrez Gene: 25272 Rat

Entrez Gene: 50658 Rat

Omim: 601158 Human

Omim: 602896 Human

Omim: 602897 Human

SwissProt: P45983 Human

SwissProt: P45984 Human

SwissProt: P53779 Human

SwissProt: Q61831 Mouse

SwissProt: Q91Y86 Mouse

SwissProt: Q9WTU6 Mouse

SwissProt: P49185 Rat

SwissProt: P49186 Rat

SwissProt: P49187 Rat

Unigene: 138211 Human

Unigene: 522924 Human

Unigene: 21495 Mouse

Unigene: 4090 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲久悠悠色悠在线播放 | 免费性片 | 久久婷婷五月综合成人D啪 成人av视频在线观看 | 久久久品 | 99精品不卡一区二区三区 | 国产精品成人免费视频 | 国产在线看片免费视频在线观看 | 又色又爽视频 | 久久久久久久波多野结衣高潮 | 在线观看中文字幕国产 | 国产日产欧产精品 | 可以免费看的av毛片 | 欧美日韩不卡一区二区 | 国产女人在线75视频 | 美国bbbbbbbbb免费毛片 | 精品无吗乱吗av国产爱色 | 国产黄色免费在线视频 | 亚洲高清久久久 | 爆乳喷奶水无码正在播放 | 狠狠躁天天躁夜夜躁婷婷 | 国产精品网址在线观看 | 任我爽橹在线视频精品583 | 沦为公交两奶头春药高潮迭起 | 亚洲综合无码日韩 | 97久久精品 | 成人免费网址 | 久久精品h | 黄色一级视屏 | 色视频在线观看免费视频 | 中文字幕一综合88久久 | 久久亚洲影视 | 国产亚洲精品欧洲在线观看 | 国产精品视频色 | 国产成人在线观看网站 | 在线成人av | 色吧av| 久久久乱码精品亚洲日韩 | 久久精品欧美精品日本韩国精品 | 中文字幕漂亮人妻熟睡中被公侵犯 | 日韩av综合中文字幕 | 高清av免费看 |