97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
成人黄色一级,久久精品女人毛片国产,天堂男人网
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-EPB41/PE-Cy3 Conjugated antibody (bs-20591R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-20591R-PE-Cy3
英文名稱 Rabbit Anti-EPB41/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的紅細胞膜條帶4.1蛋白抗體
別    名 4.1R; 41_HUMAN; Band 4.1; E41P; EL 1; EL1; Elliptocytosis 1; Elliptocytosis 1 RH linked; EPB 4.1; EPB 41; EPB4.1; Epb41; Erythrocyte membrane protein band 4.1 (elliptocytosis 1 RH linked); Erythrocyte membrane protein band 4.1; Erythrocyte surface protein band 4.1; HE; P4.1; Protein 4.1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 97kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EPB41
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The 4.1 gene family encodes a group of multifunctional cytoskeletal proteins (4.1R, 4.1G, 4.1N and 4.1B), which are predominantly expressed in the nervous system. 4.1G is a protein that stabilizes spectrin-actin interactions and is associated with hereditary elliptocytosis. Red blood cell 4.1, designated 4.1R, is a multifunctional protein that is essential for maintaining erythrocyte shape and membrane mechanical properties. Both 4.1R and 4.1G are distributed in a unique pattern in the cerebellum and are believed to modulate the membrane mechanical properties of neuronal cells by promoting fodrin/actin association. 4.1N and 4.1B, designated EPB41L1 and EPB41L3, respectively, are strongly expressed in the brain. Antibodies to 4.1N have been reported to detect mulitple forms, each enriched in postsynaptic density preparations relative to brain homogenate. Antibodies to 4.1B have been reported to detect two forms.

Function:
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.

Subcellular Location:
Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Nucleus.

Post-translational modifications:
Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.
Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.
O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.

DISEASE:
Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.

Similarity:
Contains 1 FERM domain.

Database links:

Entrez Gene: 2035 Human

Entrez Gene: 269587 Mouse

Omim: 130500 Human

SwissProt: P11171 Human

SwissProt: P48193 Mouse

Unigene: 175437 Human

Unigene: 708933 Human

Unigene: 712722 Human

Unigene: 30038 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲欧美日韩在线观看一区二区三区 | 日本在线视频播放 | 91在线小视频 | 国产又粗又硬又猛的毛片视频 | 欧美视频免费在线 | 一本到不卡免费一区二区 | 成人性生交大片100部 | yy6080午夜八戒国产亚洲 | 国产亚洲精品久久久一区 | gogogo高清在线观看免费中国 | 精品国产乱码一区二区三区麻豆 | 超碰五月天| 一本久久综合亚洲鲁鲁五月天 | 人人妻人人澡人人爽精品日 | 亚洲国产精品成人av | 久久免费播放视频 | 国产香蕉视频在线 | 18无遮挡啪啪无码网站免费看 | AV人摸人人人澡人人超碰手机版 | 天堂资源在线观看免费高清视频 | 国产无套激情在线视频 | 成av在线 | 99这里有精品视频 | 午夜精品久久久久久久99无限制 | 亚洲性专区 | 少妇大叫又粗又大太爽A片 heyzo朝桐光一区二区 | 国产福利男女XX00视频 | 免费A级毛片无码A∨中文字幕 | 国产综合高清在线观看 | 欧美群交射精内射颜射潮喷 | 欧美暧暧视频 | 一区二区三区四区影院 | 久久狠狠色噜噜狠狠狠狠97 | 久久精品一区中文字幕 | 日本三级美女 | 青青操在线 | 免费A级毛片无码A∨性按摩 | 午夜在线不卡 | 国语对白乱子 | 亚洲精品97久久中文字幕无码 | 另类色综合 |