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Rabbit Anti-FSH receptor/APC Conjugated antibody (bs-20658R-APC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-20658R-APC
英文名稱 Rabbit Anti-FSH receptor/APC Conjugated antibody
中文名稱 APC標記的促卵泡刺激素受體抗體
別    名 Follicle-stimulating hormone receptor precursor; Follicle stimulating hormone receptor; Follicle stimulating hormone receptor isoform 1; Follitropin receptor; FSHRO; LGR1; ODG1; Follicle-stimulating hormone receptor; FSH-R; FSH R; Fshr; FSHR_HUMAN; MGC141667; MGC141668; ovarian dysgenesis 1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  發育生物學  信號轉導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Sheep, )
產品應用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FSH receptor
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Function:
Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subunit:
Interacts with ARRB2.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Sertoli cells and ovarian granulosa cells.

DISEASE:
Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.

Similarity:
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.

Database links:

Entrez Gene: 281172 Cow

Entrez Gene: 100861291 Goat

Entrez Gene: 2492 Human

Entrez Gene: 14309 Mouse

Entrez Gene: 397679 Pig

Entrez Gene: 25449 Rat

Entrez Gene: 443299 Sheep

Omim: 136435 Human

SwissProt: P35376 Cow

SwissProt: P23945 Human

SwissProt: P35378 Mouse

SwissProt: P49059 Pig

SwissProt: P20395 Rat

SwissProt: P35379 Sheep

Unigene: 1428 Human

Unigene: 57155 Mouse

Unigene: 162843 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FSHR屬于G蛋白偶聯受體超家族中的糖蛋白亞家族成員,跨膜蛋白。人類的FSHR是由695個氨基酸組成的一條肽鏈,主要分布于睪丸支持細胞和卵巢顆粒細胞
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