97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
自拍理论片,亚洲毛片一区二区三区,好男人在线观看免费视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-RANKL/CD254/FITC Conjugated antibody (bs-20647R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-20647R-FITC
英文名稱 Rabbit Anti-RANKL/CD254/FITC Conjugated antibody
中文名稱 FITC標記的骨保護蛋白配體/破骨細胞分化因子抗體
別    名 OPGL; CD254; hRANKL2; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa B ligand; sOdf; SOFA; TNF related activation induced cytokine; TNFSF 11; TNFSF11; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoprotegerin Ligand; TNF11_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  發育生物學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Dog, Horse, Rabbit, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RANKL/CD254
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008].

Function:
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Subcellular Location:
Cytoplasm; Secreted and Cell membrane.

Tissue Specificity:
Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.

Post-translational modifications:
The soluble form of isoform 1 derives from the membrane form by proteolytic processing. The cleavage may be catalyzed by ADAM17.

DISEASE:
Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2) [MIM:259710]; also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development.

Similarity:
Belongs to the tumor necrosis factor family.

Database links:

Entrez Gene: 8600 Human

Entrez Gene: 21943 Mouse

Omim: 602642 Human

SwissProt: O14788 Human

SwissProt: O35235 Mouse

Unigene: 333791 Human

Unigene: 249221 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

OPGL骨保護蛋白配體又稱骨保護素配體(破骨細胞發育刺激因子)。屬腫瘤壞死因子TNF-a家族。
OPGL促進破骨細胞的分化和活性,而OPG抑制這些過程。骨髓瘤細胞影響骨髓中這兩種蛋白的生理平衡,是發生溶骨性病變的根本所在。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 中文字幕久久久久一区 | 国产色婷婷五月精品综合在线 | 最近更新中文字幕手机版 | 国偷自产一区二区视频 | 欧美一级鲁丝片 | 日韩精品一区二区三区免费观看 | 少妇大叫又粗又大太爽A片 heyzo朝桐光一区二区 | 日日爱666| 精品剧情V国产在线观看 | 日韩欧美h| 精品国产乱 | 伊甸园精品区 | 中国国语毛片免费观看视频 | 新久久久| 精品一区二区免费视频 | 国产爽爽久久影院潘金莲 | 超碰中文字幕在线 | 一区2区3区在线看 | 四虎国产精品永久地址99新强 | 日本波多野结衣在线 | 亚洲国产精品久久久久久69 | 真人在线观看色网视频 | 无码精品人妻一区二区三区老牛 | 欧美日韩国产人妻无码 | 亚洲精品久久久久中文字幕 | 国产二区久久 | 国产精品久久久尹人香蕉 | 精品国产不卡一区二区三区 | 美女把尿口扒开让男人桶爽 | 国产一区二区精品久久岳 | 在线观看黄免费 | 青青草视频精品 | 天天曰夜夜操 | 国内自拍偷拍一区 | 免费黄av | 无套内射视频囯产 | 亚洲精片 | 日本久久综合 | aaa日本高清在线播放免费观看 | 中文av一区| 成网在线看 |