97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
91成熟丰满女人少妇777,婷婷综合丁香,久久精品美女
Rabbit Anti-RANKL/CD254/Cy7 Conjugated antibody (bs-20646R-Cy7)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-20646R-Cy7
英文名稱 Rabbit Anti-RANKL/CD254/Cy7 Conjugated antibody
中文名稱 Cy7標(biāo)記的骨保護(hù)蛋白配體/破骨細(xì)胞分化因子抗體
別    名 OPGL; CD254; hRANKL2; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa B ligand; sOdf; SOFA; TNF related activation induced cytokine; TNFSF 11; TNFSF11; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoprotegerin Ligand; TNF11_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  發(fā)育生物學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RANKL/CD254
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008].

Function:
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Subcellular Location:
Cytoplasm; Secreted and Cell membrane.

Tissue Specificity:
Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.

Post-translational modifications:
The soluble form of isoform 1 derives from the membrane form by proteolytic processing. The cleavage may be catalyzed by ADAM17.

DISEASE:
Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2) [MIM:259710]; also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development.

Similarity:
Belongs to the tumor necrosis factor family.

Database links:

Entrez Gene: 8600 Human

Entrez Gene: 21943 Mouse

Omim: 602642 Human

SwissProt: O14788 Human

SwissProt: O35235 Mouse

Unigene: 333791 Human

Unigene: 249221 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

OPGL骨保護(hù)蛋白配體又稱骨保護(hù)素配體(破骨細(xì)胞發(fā)育刺激因子)。屬腫瘤壞死因子TNF-a家族。
OPGL促進(jìn)破骨細(xì)胞的分化和活性,而OPG抑制這些過程。骨髓瘤細(xì)胞影響骨髓中這兩種蛋白的生理平衡,是發(fā)生溶骨性病變的根本所在。
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 欧美激情网站在线观看 | 中文字幕第31页 | 国产最顶级的黄色片在线免费观看 | 在线观看国产中文字幕 | 亚洲丁香婷婷久久一区二区 | 国产精品久久久久9999爆乳 | 色欲av久久无码影院色戒 | 热99在线视频 | 国内精品人妻无码久久久影院蜜桃 | 午夜小视频免费 | 又嫩又紧欧美12p | 999www人成免费视频 | 精品成人毛片一区二区 | 日本精品一区二区三区视频 | 午夜无码片在线观看影视 | 人妻少妇波多野结衣 | 91精品少妇高潮一区二区三区不卡 | 麻豆福利网 | 免费观看一区二区三区毛片 | 日本福利在线 | 午夜精品成人一区二区 | 九九日视频 | 欧美性猛交视频 | 欧美乱妇无乱码大黄a片 | 2级毛片 | 成人免费A级毛片无码 | 成人精品一区二区三区免费看 | 99久久免费国产 | 亚洲国产天堂久久综合网 | 女人高潮一级一片 | 国产一区二区在线91 | 日本免费在线视频观看 | 性高朝久久久久久久 | 精品人妻一区二区三区四区在线 | 91精品国产综合久久久久久蜜月 | 国产精品网站在线 | 亚洲精品无码精品MV在线观看 | 亚洲福利在线播放 | 性色AV一区二区三区V视界影院 | 91九色婷婷 | 亚洲精品18 |