97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關于我們  聯(lián)系我們
久久久久亚洲国产精品,天天色婷婷,亚洲婷婷中文字幕
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-PSD95/Gold Conjugated antibody (bs-20649R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-20649R-Gold
英文名稱 Rabbit Anti-PSD95/Gold Conjugated antibody
中文名稱 膠體金標記的突觸后密度蛋白95抗體
別    名 Discs large homolog 4; Disks large homolog 4; DLG 4; DLG4; DLG4_HUMAN; FLJ97752; FLJ98574; Human post synaptic density protein 95; Human post-synaptic density protein 95; Post synaptic density protein 95; Postsynaptic density protein 95; PSD 95; PSD-95; PSD95; SAP 90; SAP-90; SAP90; Synapse associated protein 90; Synapse-associated protein 90; Tax interaction protein 15.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  免疫學  神經(jīng)生物學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PSD95
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.

Subunit:
Interacts with ANKS1B, KLHL17 and PRR7. Interacts through its PDZ domains with NETO1. Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ACCN3, certain splice forms of GRIN1, KCND2, CXADR and SYNGAP1. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. May interact with HTR2A. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A and BEGAIN. Interacts through its third PDZ domain with CRIPT (By similarity). Interacts through its first two PDZ domains with KCNA1, KCNA2, KCNA3, KCNA4 and ERBB4. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with KIF13B. Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK. Interacts with LRFN1, LRFN2 and LRFN4. Interacts with ANO2, ADAM22 and LGI1. Interacts with FRMPD4 (via C-terminus). Interacts (via PDZ1 and PDZ2 domains) with LRRC4; LRRC4B and SEMA4C. Interacts (via guanylate kinase-like domain) with SIPA1L1.

Subcellular Location:
Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cell junction, synapse, synaptosome. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.

Tissue Specificity:
Brain.

Post-translational modifications:
Palmitoylation of isoform 1 is required for targeting to postsynaptic density.

Similarity:
Belongs to the MAGUK family.
Contains 1 guanylate kinase-like domain.
Contains 3 PDZ (DHR) domains.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 1742 Human

Entrez Gene: 13385 Mouse

Entrez Gene: 29495 Rat

Entrez Gene: 100137840 Cow

Omim: 602887 Human

SwissProt: P78352 Human

SwissProt: Q62108 Mouse

SwissProt: P31016 Rat

Unigene: 463928 Human

Unigene: 27256 Mouse

Unigene: 9765 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

該蛋白質(zhì)PSD95能夠幫助建立神經(jīng)突觸的架構(gòu),并且促成突觸其他部分的成熟,例如加強目標細胞上的glutamate受體的聚集、增加樹突棘(dendritic spines)的數(shù)量和大小以及增加神經(jīng)傳導物質(zhì)glutamate (谷氨酸鹽)釋放的量。這種蛋白質(zhì)與阿滋海默癥有關。
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 久久久久久国产精品免费免费狐狸 | 香港三级精品三级在线专区 | 亚洲精品无码AV中文字幕 | 成人av中文解说水果派在线观看 | 97久久夜色精品国产九色 | 国产成人涩涩涩视频在线观看 | 国产性生大片免费观看性 | 少妇大胆瓣开下部自慰 | 免费观看一级 | 国产精品222 | 亚洲三级中文字幕在线看 | 精品国偷自产在线视频 | 国产精品男人影院在线播放 | 青青草91久久久久久久久 | 两人视频在线播放免费观看网站 | 人人射人人爽 | www.国产91| 992tv精品视频tv在线观看 | 人人澡人人曰人人摸看 | 免费观看日韩视频 | 日韩欧美精品一区二区三区经典 | 大地资源二中文在线观看官网 | 懂色av影视一区二区三区 | 少妇高潮毛片 | 亚洲高清久久久 | av中文在线资源 | 国产精品无| 亚洲精品有限公司 | 国产66精品久久久久999小说 | 成人性生交大片免费看中国A片 | 手机看片日韩日韩 | 欧美国产成人精品二区芒果视频 | 欧美亚洲日韩国产网站 | 久久精品一二 | 日产中文字幕在线观看 | 亚洲乱伦精品免费 | 91在线看网站 | 一区二区三区日本 | 国产高清免费在线播放 | 美国产一级片 | x88av入口av在线 |