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Rabbit Anti-beta 2 Microglobulin/PE-Cy3 Conjugated antibody (bs-0390R-PE-Cy3)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0390R-PE-Cy3
英文名稱 Rabbit Anti-beta 2 Microglobulin/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的β2-微球蛋白抗體
別    名 B2M; Beta-2-MG; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Hdcma22p; B2MG_HUMAN; Beta-2 microglobin; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Beta chain of MHC class I molecules; Beta-2-microglobulin form pI 5.3; CDABP0092.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, 
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 13/27kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human Beta-2-Microglobulin protein
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009].

Function:
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Subunit:
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.

Subcellular Location:
Secreted. Note=Detected in serum and urine.

Post-translational modifications:
Glycation of Ile-21 is observed in long-term hemodialysis patients.

DISEASE:
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.

Similarity:
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 567 Human

Entrez Gene: 12010 Mouse

Entrez Gene: 24223 Rat

Omim: 109700 Human

SwissProt: P61769 Human

SwissProt: P01887 Mouse

SwissProt: P07151 Rat

Unigene: 534255 Human

Unigene: 702947 Human

Unigene: 163 Mouse

Unigene: 1868 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

小鼠抗人β2微球蛋白在中樞神經系統感染、腫瘤及全身性自身免疫性疾病患者腦脊液中,會出現β2MG蛋白不同程度的增高。
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